Targeting inflammatory protein could help treat severe asthma

April 17, 2024

“In some people, the inflammation is resistant to steroids – the first treatment option for controlling severe asthma. “Currently, limited treatment options are available for severe asthma. New and existing drugs often only target single molecules when multiple overlapping cells and inflammatory pathways are responsible for asthma. 2022 marked the highest asthma deaths since 2017, partly driven by the post-Covid return of viral respiratory infections which are associated with increases in asthma hospitalisations. DOI: 10.1016/j.jaci.2023.10.021*The Centre for Cancer Biology is an alliance between the University of South Australia (UniSA) and CAHLN/SA Pathology.

26 February 2024

Just weeks after news of a sharp national spike in asthma deaths – with South Australia recording the highest increase in a single year (88%) – scientists have revealed a promising new treatment for the chronic lung disease.

Australian researchers have found that a family of proinflammatory molecules called beta common cytokines control inflammation and scarring of the airways (fibrosis) in severe and steroid-resistant asthma.

They believe that a human therapeutic antibody called trabikihart could be the key to effectively blocking the inflammation and scarring.

The findings, published in the Journal of Allergy and Clinical Immunology, are a result of a joint study led by researchers from the University of South Australia (UniSA) and the Royal Melbourne Institute of Technology (RMIT), in collaboration with researchers from CSL and SA Pathology.

Joint study leader Dr Damon Tumes, Head of the Allergy and Cancer Immunology Laboratory in the Centre for Cancer Biology*, says the findings are significant.

“Inflammation and tissue damage in severe asthma is caused by several types of immune cells that enter the lungs due to allergens, viruses and other microbes that interact with the airways,” Dr Tumes says.

“In some people, the inflammation is resistant to steroids – the first treatment option for controlling severe asthma.

“Currently, limited treatment options are available for severe asthma. New and existing drugs often only target single molecules when multiple overlapping cells and inflammatory pathways are responsible for asthma.

“Targeting multiple inflammatory cytokines with a single drug may be the key to treat and control complex and severe chronic airway disease.”

The most recent statistics show a 30% rise in asthma-related deaths (467 people) nationally in 2022, with South Australia recording the most drastic increase at 88%.

According to experts, most of the deaths were preventable and were linked to people not having treatment on hand, or using it as prescribed, especially inhaled corticosteroids.

2022 marked the highest asthma deaths since 2017, partly driven by the post-Covid return of viral respiratory infections which are associated with increases in asthma hospitalisations.

Widespread rainfall, triggering an increase in fungal spores and pollen, is also a factor.

Notes to editors

“Dual inhibition of airway inflammation and fibrosis by commonβcytokine receptor blockade” is published in the Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2023.10.021

*The Centre for Cancer Biology is an alliance between the University of South Australia (UniSA) and CAHLN/SA Pathology.

 

…………………………………………………………………………………………………………………………

Media contact: Candy Gibson M:  0434 605 142 E: [email protected]

Lead researcher: Dr Damon Tumes E: [email protected]

 

The source of this news is from University of South Australia

Popular in Research

1

May 13, 2024

For MIT students, there is much to learn from crafting a chair

2

4 days ago

Putin ‘launches space weapon’ while his forces carry out nuke drill near Ukraine

3

May 19, 2024

Persistent “hiccups” in a far-off galaxy draw astronomers to new black hole behavior

4

1 week ago

“Life is short, so aim high”

5

May 13, 2024

HKUST Researchers Develop Revolutionary Biomimetic Olfactory Chips to Enable Advanced Gas Sensing and Odor Detection | The Hong Kong University of Science and Technology

'General Hospital' Actor Johnny Wactor Shot, Killed During Robbery Attempt

8 hours ago

Kari Lake Blasts Abortion Ban She Once Was ‘Thrilled’ About

1 day ago

Trump is about to go on trial in New York. Here's what to expect

8 hours ago

How Donald Trump Still Lives in the 1980s

1 day ago

COOL COURSE: Teaching Tech to Artists Gives them ‘Magic Power’

1 day ago

For Julie Greenberg, a career of research, mentoring, and advocacy

1 day ago