Novel triple drug combination effective against antibiotic-resistant bacteria

Finding new and innovative ways of combatting antibiotic resistance, such as developing new drug combinations using novel agents with existing antibiotics, is valuable in the fight against infectious disease. One effective strategy to restore the activity of the antibiotic is to use a combination therapy to counter bacterial resistance mechanisms. An antibiotic combination treatment includes an antibiotic and an inhibitor. ">Video of New triple drug combination effective against antibiotic resistant bacteriaThis study builds on our previous work to develop broad spectrum metallo β-lactamase inhibitors. The findings provide a benchmark for the activity of a single ideal molecule which can evade bacterial resistance mechanisms.