Prof Helen McShane Chief Investigator, TB Vaccine Trials Jenner Institute, University of Oxford, said:TB kills more people than any other infectious disease and we urgently need better vaccines. If eligible, volunteers will either receive BCG vaccine either as an injection in the skin or as an inhaled vaccine. The BCG vaccine works well against disease in childhood, but it is not good enough at protecting against disease in adulthood, which is when the majority of TB deaths occur. A significant proportion of the population infected with TB continue to get sick and die even with TB medication. Having a new way of optimizing the BCG vaccine will ultimately improve the health of people all over the world.