AI reveals prostate cancer is not just one disease

A Cancer Research UK-funded study, published in Cell Genomics, has revealed that prostate cancer, which affects one in eight men in their lifetime, includes two different subtypes termed evotypes. The team hope their findings could save thousands of lives in future and revolutionise how prostate cancer is diagnosed and treated. The ground-breaking research, which involved additional funding from Prostate Cancer Research and involved scientists from the University of Oxford, the University of Manchester, the University of East Anglia and the Institute of Cancer Research, London, highlights how a prostate cancer diagnosis can affect physical, emotional and mental wellbeing. The researchers used AI to study changes in the DNA of prostate cancer samples (using whole genome sequencing) from 159 patients. The paper 'Genomic evolution shapes prostate cancer disease type' is published in Cell Genomics.