26 Oct 2023Job Information
First Stage Researcher (R1)
1 Dec 2023 - 12:00 (Europe/Paris)
Type of Contract
Offer Starting Date
1 Jan 2024
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
The PanCaIKS (Pan-Cancer Imaging and Killing Strategy) ANR project aims to develop an original receptor-specific radiolabeled peptide for bad prognosis tumor imaging and therapy. The radiopeptide, mimicking the C-terminal Binding Domain (CBD) of Thrombospondin-1 (TSP-1) will target the CD47 receptor, overexpressed by cancer cells.
In this project, our task is to provide bifunctional macrocyclic ligands optimized for the different families of radiometals envisaged. Despite dota chelator and its derivatives are widely explored for the complexation of radiometals in preclinical studies, in some cases they display a lack of selectivity which compromises the use of the associated radioelement in vivo. Therefore, the design of radiopharmaceutical tools, for both cancer treatment and imaging, requires expanding i) the repertoire of the chelators to molecules not leading to a release of the radioisotope in vivo and ii) the associated radiometals (b- or a emitters for therapy; b+ or g emitters for TEP or SPECT, respectively), including “theranostic pairs” whose constitute ideal theranostic tools while requiring the exploration of a unique associated chelator.
In a later stage, the radiopeptide will be evaluated in vitro on pan-cancer cell lines. Pancreas and Triple Negative Breast Cancers will be chosen as models for the in vivo proof of concept (POC). This is an original approach since this receptor has not been targeted in the field of Peptide Receptor Radionuclide Therapy (PRRT) until now.
The young researcher, localized in the CEMCA Laboratory (UMR 6521) will have a serious background in organic chemistry (and if possible in macrocyclic chemistry). A good knowledge in bioconjugation reactions (click chemistry, NHS, maleimide…) as well as an expertise in purification by HPLC will also be important additional assets. The post-doc will also have an affinity for bio- applications and will frequently interact with the different partners of the project.Requirements
PhD or equivalent
We are looking for a motivated and experienced candidate in organic synthesis with a strong openness to coordination chemistry and health applications, particularly in imaging / nuclear medicine. A good knowledge in thermodynamic and kinetic studies as well as an expertise in the synthesis and purification of metal complexes by HPLC will be important. The young researcher will also have to explore the structural studies of the complexes and will frequently interact with the other partners including the peptide-conjugated studies. One internship with our collaborator is expected to include peptide conjugation in his/her PhD works and final skills.
Internal Application form(s) needed
Annonce post-doc ANR.pdf
(163.86 KB - PDF)
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Number of offers available
University of Brest
GeofieldWhere to apply
https:// www. univ-brest.fr/cosm/menu/RechercheResearch/Macrocycles-azotes-et- coordination
6 Avenue Le Gorgeu