PhD Student in Cancer Evolution

Deutsches Krebsforschungszentrum
March 14, 2023
Offerd Salary:Negotiation
Working address:N/A
Contract Type:Other
Working Time:Negotigation
Working type:N/A
Ref info:N/A
Position:PhD Student in Cancer Evolution

Department: DKTK partner site Munich, Department of Medicine III (University Hospital of Munich, LMU, Spiekermann lab) and the Core Facility "Mouse Models of Acute Leukemias" (HMGU / Jeremias lab)

Code number: 2023-0058

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).

At the DKTK partner site Munich the Department of Medicine III (University Hospital of Munich, LMU, Spiekermann lab) and the Core Facility "Mouse Models of Acute Leukemias" (Helmholtz Munich / Jeremias lab) are offering a PhD position as part of the programs „Molecular Diagnostics, Early Detection and Biomarker Development“ and „Exploitation of Oncogenic Mechanisms“.

Job description:

Therapy resistance is a major problem in cancer therapy resulting in cancer recurrence and finally therapy failure. This translational project focusses on acquired mechanisms of resistance towards targeted agents in acute leukemias with a focus on Antibody Drug Conjugates (ADC). Multi-omics characterization of in vitro and in vivo models of drug resistance will be used to identify candidates for functional characterization. Moreover, clinical samples will be characterized to validate findings from model systems in human disease.

The project will require approximately 50% wet lab und 50% dry lab work.


  • Above-average master's or diploma degree in medical or life sciences (biology or a related discipline)
  • Experience with techniques of molecular biology and interests in cell culture, protein analysis and molecular biology (mutagenesis, cloning, expression, gene knockouts with CRISPR/Cas)
  • Interest in bioinformatics and experience with R (programming / statistics)
  • Excellent communication skills in English, spoken and written
  • Eagerness to learn and contribute to future cancer characterization, in particular working with genome-wide expression, mutation and DNA methylation data
  • Enjoy working in a dynamic, interdisciplinary environment (lab medicine, clinics)
  • Strong motivation, scientific curiosity and commitment to scientific excellence
  • We offer:

  • Interesting, versatile workplace
  • International, attractive working environment
  • Campus with modern state-of-the-art infrastructure
  • Access to international research networks
  • Doctoral student payment including social benefits
  • Flexible working hours
  • Comprehensive training and mentoring program through the Helmholtz International Graduate School
  • Important notice:

    The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.

    Earliest Possible Start Date: as soon as possible

    Duration: The position is limited to 3 years. ​​

    Application Deadline: 14.03.2023


    Christine Koppenhöhl Phone +49 (0)89/4400-54627

    Please note that we do not accept applications submitted via email.

    The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

    Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

    To apply for a position please use our online application portal (https: // www.

    We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

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