Differentiation of Pluripotent Stem Cells
Job No.: 654350
Location: Clayton campus
Employment Type: Full-time
Duration: 3-year fixed-term appointment with possible 6-month extension
Remuneration: $34,013 p.a.
PhD Project - Surface Modified Materials for the Directed Differentiation of Induced Pluripotent Stem Cells to T-Cells.
Main Supervisor - Professor Laurence Meagher
Cancer is one of the leading causes of death, accounting for almost 10 million deaths in 2020 (1 in 6). The use of immune cells to treat cancer (for example CAR T cell therapies) is gaining immense traction globally. Five of these types of products have recently gained approval for use in the treatment of various types of cancer. However, the production of these types of cells is often very costly due to the complex manufacturing process and that many of the therapies in development are individual, patient specific, therapies requiring harvesting of the cancer patient's own cells. One approach to reduce the manufacturing of the cells is to use pluripotent stem cells and use a material-based approach to instruct the directed differentiation of the PSCs to specific immune cell types. This project will use surface modification approaches to direct differentiation efficiently and reproducibly to allow larger scale expansion and reduce manufacturing costs. The research will be conducted in the group of Professor Laurence Meagher, in collaboration with research groups at Monash University.
The ARC Training Centre for Cell & Tissue Engineering Technologies (ARC CTET) is a Research Centre led by Monash University in collaboration with QUT and 22 industry partner organisations. The successful applicant will work closely with a Melbourne-based Biotechnology company, focusing on the development of immune cells for the treatment of cancer.
Applicants should have previous research and laboratory experience in related fields such as surface modification of polymeric materials, surface and molecular characterisation, biomaterial development, cell culture and bioassays. Applicants must show excellent communication and interpersonal skills, and the potential to conduct self-motivated research. They should have an Honours or Master's Degree (or equivalent).
Note: Applicants who already hold a PhD will not be considered.
Please contact [email protected] for more information or to apply
Sunday 15 October 2023, 11:55pm AEST
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