Exploration Of Antiviral And Antimicrobial Fusion Peptides Activities

19 May 2023

Job Information

Organisation/Company

CY Cergy Paris University

Department

Chemistry

Research Field

Chemistry » Organic chemistry

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

19 Jun 2023 - 12:00 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

1 Oct 2023

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The emergence of new infectious agents, caused by globalization, climate change, increasing of the population, etc. leads to the need of new drugs and must be considered in a one-Health approach since the barrier between species is limited. As an example, the magnitude of the morbidity and mortality during the Covid-19 pandemic showed that the discovery and the development of effective antiviral drugs are an urgent priority. Moreover, phenomena of microbial resistance lead us to consider new molecular structures and new therapeutic targets. 1 We propose to combine the needs of antivirals and antimicrobials by appropriate modifications of fusion viral peptides. 2

The objectives of this project are to study the antiviral and antibacterial properties of viral fusion peptides. After selection of relevant viral fusion peptide sequences, native hydrophobic sequences as well modified sequences will be synthesized to study their ability to inhibit the viral fusion step. Different modifications will be introduced in order to allow interaction with bacterial membranes to change physicochemical properties and improve their amphipathic character. 3 Membranotropic properties will be evaluated by spectrofluorescence. 4 Because antimicrobial peptides often act via a pore formation, we will then study the ability of the new analogues to form pores in the bacterial wall and their behavior inside the pores. 5 These properties will be correlated with their biological activities (antiviral: University of Gdansk, antimicrobial: CY University) and to conformational studies (University of Naples, University of Paris-Saclay).

Requirements

Research Field

Chemistry » Organic chemistry

Education Level

Master Degree or equivalent

Skills/Qualifications

Master in chemistry or chemical engineering.

Background in organic and/or peptide synthesis. Knowledge in medicinal chemistry, drug design,

cells studies, biophysics would be appreciated

Languages

ENGLISH

Level

Good

Languages

FRENCH

Level

Basic

Research Field

Chemistry » Organic chemistry

Internal Application form(s) needed

PhD proposal 2023.pdf

English

(199.24 KB - PDF)

Download

Additional Information

Selection process

Candidates should send a CV, a motivation letter, transcripts of academic records

interview

Website for additional job details

https: // biocis.cyu.fr/

https: // www. biocis.universite-paris-saclay.fr/?-LCB-=

Work Location(s)

Number of offers available

1

Company/Institute

CY Université

Country

France

State/Province

95

City

Cergy-Pontoise

Postal Code

95000

Street

5 mail gay-Lussac, Neuville sur Oise

Geofield

Number of offers available

1

Company/Institute

CY Université

Country

France

City

CERGY-PONTOISE

Postal Code

95031

Street

CY Cergy paris Université

Geofield

Where to apply

E-mail

[email protected]

Contact

City

Neuville/Oise

Website

https: // biocis.cyu.fr/

Street

5 Mail Gay Lussac

Postal Code

95000

E-Mail

[email protected]

[email protected]

STATUS: EXPIRED