Doctoral Student In Medical Science - Analytical Chemistry/Neurochemistry
Göteborg University
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Doctoral position in Medical Science
Project title: Mass Spectrometry Imaging of Alzheimer Pathology
The Department of Psychiatry and Neurochemistry is located at the Institute of Neuroscience and Physiology at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg. At the Department research is conducted on human behaviour, neuropsychiatric processes as well as psychiatric treatment and diagnosis in close collaboration with Västra Götaland region and a number of international partners. We participate in the undergraduate programmes in Medicine and within The National Research School in Psychiatry/Southwest Sweden. At the Department there are some 15 research groups and four research centers.
General information about being a doctoral student at the University of Gothenburg can be found on the university's doctoral student pages https: // medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=true
Duties
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https: // www. gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Current efforts of dealing with Alzheimer's disease (AD) pose an immense societal challenge, particularly as there are still no curative treatments as the pathogenic mechanisms of AD are not understood. The major hallmark of AD is the progressive accumulation of Aβ and hyperphosphorylated- tau protein, into intra- and extracellular deposits. Although Aβ has been suggested to be a critical inducer of seeding neurotoxic plaque and tangle pathology, the exact mechanisms underlying Aβ plaque pathology remain elusive. The aim of this PhD project is to develop and apply novel chemical imaging methods based on mass spectrometry imaging (MSI) to study biochemical changes in brain tissue in both genetic mouse models of AD as well as in Alzheimer patients. Here, the project mainly involves MSI method development for advanced spatial metabolomics, lipidomics and peptide imaging at the single cell level. The goal is to understand where, when and how Aβ plaques form in the brain, how those plaques interact with the surrounding cellular environment and eventually how different plaque types are involved in neurotoxic effects downstream.
This research is an exciting NIH funded collaborative effort between the University of Gothenburg, Sweden; University College London and Northwestern University, USA. We are looking for a motivated and ambitious candidate with background in either chemistry, biochemistry, pharmacy, molecular biology, or similar for studying pathomechanisms of Alzheimer's disease in situ and in vivo using spatial biology techniques, mainly based on mass spectrometry imaging (MSI). Documented experience and expertise in mass spectrometry or/and tissue imaging using MSI is an advantage.
Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.
Eligibility
Education at third-cycle level requires general eligibility and specific eligibility as set out in the general syllabus for the subject.
The general eligibility requirements for education at third-cycle level are: 1. having completed a degree at second-cycle level, or 2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or 3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad.
Specific entry requirements for this subject, according to the general syllabus, are: having completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
Assessment criteria
The selection of applicants who are considered to have the ability required to benefit from the study programme and who meet the general and specific eligibility requirements are assessed based on the following documented qualifications: - specific knowledge and skills within the subject area and related research fields - experience of scientific theory and relevant research methodology - scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
Employment
Once you have been admitted for education at third-cycle level, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at third-cycle level for four years.
Location: Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry. Extent: 100%. First day of employment: as agreed.
The University applies a local agreement on salaries for doctoral students.
Contact information
For more information about the project please contact principal supervisor, Jörg Hanrieder, Associate Professor, Institute of Neuroscience and Physiology, e-mail: [email protected]
Unions
Union representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
Application
You can apply to be admitted for education at third-cycle level via the University of Gothenburg's recruitment portal. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.
You must include the following, in pdf format
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier .
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
For information on what you need to submit in order to fulfill the English language requirement see https: // www. universityadmissions.se/en/entry- requirements/english-language-requirements/
Applications must be received by: 2024-04-04
Information for International ApplicantsChoosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:
https: // www. gu.se/en/about-the-university/welcome-services https: // www. movetogothenburg.com/
The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.