The Placebo-controlled randomised trial of tecovirimat in non-hospitalised monkeypox patients (PLATINUM) study will test the efficacy and safety of tecovirimat, an antiviral treatment originally developed for smallpox. It is currently in use for the treatment of patients with severe complications of monkeypox who are admitted to hospital. However, to date there have been no clinical trials to confirm whether the drug can help monkeypox patients recover from the disease. Unlike RECOVERY, which recruited hospital patients, PLATINUM will be a community-based trial, with participants taking the treatment or placebo in their own homes. ‘Led by the same experts behind the world-leading COVID-19 RECOVERY trial – which developed ground-breaking treatments for patients – this new monkeypox treatment trial will test the effectiveness of the antiviral tecovirimat in fighting the disease.