The study of how cancer cells alter the glycosylation of cell surface proteins and how these modifications alter interactions between tumor cells and their environment: ECM, epithelial cells and immune system. Glycosylation is regulated by the GALA pathay. The project aims to establish whether pancreatic tumors activate GALA and whether a GALA specific treatment can improve outcomes.
The group “ Glycosylation, Cellular INterfaces and Therapies” (GLYNTHERA) is newly formed and funded by an Excellence Chair from Amidex and the ARC grant “International Leaders in Oncology”. The position will be funded at a competitive level.
Nguyen AT, Chia J, Ros M, Hui KM, Saltel F, Bard F. Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis. Cancer Cell. 2017 Nov 13;32(5):639–653.e6. PMID: 29136507
Ros M, Nguyen AT, Chia J, Le Tran S, Le Guezennec X, McDowall R, Vakhrushev S, Clausen H, Humphries MJ, Saltel F, Bard FA. ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. Nat Cell Biol. 2020 Nov;22(11):1371–1381. PMID: 33077910Benefits
Based on experience and following INSERM guidelines.
The Euraxess Center of Aix-Marseille Université informs foreign visiting professors, researchers, postdoc and PhD candidates about the administrative steps to be undertaken prior to arrival at AMU and the various practical formalities to be completed once in France: visas and entry requirements, insurance, help finding accommodation, support in opening a bank account, etc. More information on AMU EURAXESS Portal.Selection process
CV, motivation e-mail and 2 recommendation letters
Applications must be sent to Mr. Frédéric Bard : firstname.lastname@example.orgOffer Requirements Skills/Qualifications
Analytical and critical thinking, good written and oral communicationContact Information