Project assistant position in molecular imprinting

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We are looking for

Project assistant (MSc) in Molecularly Imprinted Polymer (MIP) based receptors for post-translationally modified proteins.

Work duties

This is an exciting opportunity for a highly motivated researcher to work on the next generation MIP based receptors, nanosensors and nanoscale enrichment techniques for posttranslationally modified proteins at the interface between supramolecular, polymer, analytical and bio- chemistry. The position is within the Biofilms Research Center for Biointerphases at Malmö University and is part of a multi-partner EU project.

Advances in precision medicine and related analytical and molecular biology techniques have led to a sharp increase in the number of traceable biomarkers with disease relevance. This in turn has brought new opportunities to target therapies to the individual patient, resulting in significant improvements in treatment results. Proteins and their post-translational modifications (PTMs) are particularly informative here because they are the direct cellular drivers that reflect the real-time status of cells, tissues and organ. Although we can map all human proteins in cells using mass spectrometry, our understanding of how they are regulated by PTM remains limited. Enabling in this context has been the availability of affinity reagents (e.g. antibodies) or materials (e.g. molecularly imprinted polymers, MIPs) for specific PTM enrichments. In this project you will explore molecular imprinting techniques to address two PTMs posing significant analytical challenges, namely phosphorylation and methylation, the former with a direct connection to cancer precision medicine while the latter represents a relatively "new" PTM, underexplored due to lack of effective affinity reagents. You will design and develop nano- or micron-sized MIPs targeting specific phosphopeptide biomarkers or methylated amino acids (meHis, meLys) and implement these in deep proteome analytical techniques (e.g. LC-MS/MS) or nanosensors in partner laboratories.

Qualifications

The successful candidate has a MSc degree in chemistry, preferably organic or analytical chemistry. Experimental laboratory experience is required.

Specific requirements for this position: We are seeking a highly skilled and enthusiastic student with a PhD degree in chemistry in fields with relevance to the project tasks. The following skills are required:

Good knowledge and interest in chemistry laboratory research

Practical experience in organic or analytical chemistry

Written and spoken English at a professional level.

Interest in and ability to learn new techniques

Ability to work independently and in a team

The following would be of benefit for the position:

Experience in the field of molecular imprinting and related research

Practical experience in protein chemistry and proteome analytical techniques

Experience with nanosensors

In addition to formal competence, University employees must possess the personal capacities necessary to perform the duties of the position well and to represent the University in the best possible way.

Faculty, Department and Research environment

The Department of Biomedical Science at the Faculty of Health and Society (www. mau.se/bmv) offers two bachelor's programmes that also lead to a professional degree, prescriptionist (first cycle, 180 credits) and biomedical analyst (first cycle, 180 credits), and a master's programme in biomedical surface science (second cycle, 120 credits), as well as freestanding courses at undergraduate and advanced level. The department works in what arises in the streams of knowledge from biology, chemistry, physics and medicine. The interdisciplinary education and research conducted aims to broaden the knowledge base and translate the knowledge into applications. In this interaction between knowledge building and application, our students are out in pharmacies, clinics, hospital laboratories and companies. Our researchers constantly challenge boundaries between scientific specialisations, between basic and applied research, and between academia and industry.

The research at the department is also linked to the research center "Biofilms - Research Center for Biointerfaces" (www. mau.se/brcb), which combines pharmacy, biomedical science with clinical and translational research with pharmaceutical, medical, dental, food and environmental application areas in close collaboration with regional industry.

Further information

Börje Sellergren, Professor in Biomedical Technology. Phone: +46 40 665 7810, EMail: [email protected].

Magnus Jakobsson, Associate Director, Proteomics, Acrivon Therapeutics Inc. Email: [email protected]

For general questions regarding employment at Malmö University, please contact: HR specialist Heidi Francke (HR specialist), [email protected]

In our recruitment work, Malmö University has taken a stand regarding recruitment channels and marketing. We therefore decline all offers of advertising and recruitment assistance in connection with this advertisement.

You can read more about the benefits of working in Sweden here: https: // sweden.se/collection/working-in-sweden/

Application

You apply for this position via Malmö University's recruitment system by clicking on the "Apply" button. As an applicant, you are responsible for ensuring that your application is completed in accordance with the job advertisement, and that it is submitted to the University no later than September 19th, 2023. The application must be written in Swedish, English or any of the Nordic languages. As an applicant, you are responsible for the application and its appendices being translated.

The application must include:

Curriculum Vitae

Copies of relevant degrees and certificates

A brief account on a maximum of one page, where you describe your experience, background and competence related to the applied position that makes you the most suitable candidate

Miscellaneous

This is a full-time, fixed-term employment of 1 year.

Malmö University is a workplace and higher education institution that is characterised by an open and inclusive approach, where gender equality and equal terms add value to our activities.

Malmö University applies individual salary setting.

Start date

October 1, 2023

Union representatives

SACO-S: Ann-Mari Campbell, [email protected]

Teachers' Union: Charlotte Paggetti, [email protected]

ST/OFR: Aje Carlbom [email protected]

We are looking forward to receiving your application!