Postdoctoral Position In Cellular Microbiology/Immunology (H/F)

Universities and Institutes of France
November 03, 2022
Contact:N/A
Offerd Salary:Negotiation
Location:N/A
Working address:N/A
Contract Type:Temporary
Working Time:Full time
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Job Ref.:N/A
  • Organisation/Company: CNRS
  • Research Field: Biological sciences Medical sciences Pharmacological sciences
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 03/11/2022 23:59 - Europe/Brussels
  • Location: France › MONTPELLIER
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 02/01/2023
  • - Bacteria and cell culture - Molecular and cellular biology techniques: cloning, ectopic expression, qPCR, immunoprecipitation, Western blot analysis, immunofluorescence, ELISA - Microscopy: bright field, fluorescence, confocal - Flow cytometry - Common laboratory duties: buffer preparation, stock management

    - Literature analysis

    - PhD student co-supervision

    - Scientific article writing and editing

    Manipulation of cytosolic sensors by the stealth bacterial pathogen Coxiella burnetii Our laboratory focuses on host/pathogen interactions occurring during infection with the intracellular bacterial pathogen Coxiella burnetii, the causative agent of the zoonosis Q fever. This stealth bacterium can invade and develop in a wide range of cell types, such as macrophages and trophoblasts. Coxiella possesses a Dot/Icm Type 4b Secretion System (T4SS) that allows the secretion of bacterial effector proteins. These effectors participate in the formation of an intracellular replicative niche named Coxiella-Containing Vacuole (CCV) as well as the inhibition of apoptosis. Our laboratory and others have shown that Coxiella can dampen the inflammatory response of infected cells to promote intracellular persistence (Mahapatra et al., 2016, Burette et al., 2020, Cunha et al., 2015). Recently, we have identified additional effectors capable of interacting with several cytosolic sensors of the NOD-like receptors family (NLRs), which play a crucial role in the recognition of intracellular pathogens and the inflammatory response of immune and placental cells. The role of the candidate will be to characterise these newly identified effector proteins and determine how Coxiella manipulates host NLRs to evade the innate immune response. This is an exciting opportunity to better understand Coxiella's stealth strategies of infection.

    The laboratory is composed of 10 scientists (Senior, junior, lecturer, engineers and PhDs) and is hosted in the Infectiology Research Institute of Montpellier (France), which is supported by the CNRS and the University of Montpellier. The Institute is composed of 11 teams working at the forefront of research on bacterial and viral diseases. It provides an exciting, multi- disciplinary and multi-cultural environment, and is connected to state-of-the- art facilities in microbiology (BSL2 and BSL3), microscopy, cytometry and mass spectroscopy.

    Eligibility criteria

    - Technical skills in cellular microbiology and immunology - Communication skills in English (written and oral) - Team spirit

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/CDD/UMR9004-ERIMAR-001/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Biological sciences

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Medical sciences

  • YEARS OF RESEARCH EXPERIENCE
  • None

  • RESEARCH FIELD
  • Pharmacological sciences

  • YEARS OF RESEARCH EXPERIENCE
  • None

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

    Medical sciences: PhD or equivalent

    Pharmacological sciences: PhD or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Institut de Recherche en Infectiologie de Montpellier
  • Organisation Type: Public Research Institution
  • Website: https:// www. irim.cnrs.fr/
  • Country: France
  • City: MONTPELLIER
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