Postdoc Or Engineer In Biology And Computational Neurosciences

Universities and Institutes of France
October 14, 2022
Contact:N/A
Offerd Salary:Salary : between 48.000 and 70
Location:N/A
Working address:N/A
Contract Type:Temporary
Working Time:Full time
Working type:N/A
Job Ref.:N/A
  • Organisation/Company: CNRS
  • Research Field: Biological sciences
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 14/10/2022 21:00 - Europe/Brussels
  • Location: France › Marseille
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/01/2023
  • This project aims at modelling behaviors in five autism spectrum disorder (ASD) mouse models, caused by genetic mutations or by excessive gestational weight gain (GWG, detected today in half of the women), or a combination of both. We will join the complementary expertise of three teams from three laboratories to investigate lifelong the « spontaneous behavior » of mice freely moving into an open space, by using a recently developed system based on novel and evolutive tools (Live Mouse Tracker - LMT https: // livemousetracker.org, DeepLabCut - DLC https:// www. mackenziemathislab.org/deeplabcut).

    Behaviors of all living beings consists of patterns in time: identifying this set of patterns available to an animal is key to making quantitative descriptions of behavior. We thus propose a 3D behavioral analysis pipeline dedicated to the study of temporal series of single actions (including individual, dyadic or group actions). This framework will rely on computer vision (tracking, pose recognition, ….) and recent deep learning techniques (transformers, auto-encoders, …), and will consider these action time series at multiple time-scales.

    The main goal of this project is then to analyze and compare behavioral motifs and sequences in different mouse models of ASD compared with controls in order to identify common or specific behaviors for each model. We will also evaluate the effect of gestational obesity on autistic behaviors of mice with mutations in genes involved in autism.

    Part 1: modeling complex locomotor activity applied to several mouse models of ASD.

    Part 2: Identify novel autistic behavioral motifs and sequences in mouse models of ASD compared with controls.

    Salary : between 48.000 and 70.000 euros/year depending on experience

    Duration of the contract : 3 years

    The start date is flexible and planned for early 2023.

    Required Research Experiences
  • RESEARCH FIELD
  • Biological sciences

  • YEARS OF RESEARCH EXPERIENCE
  • 1 - 4

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: PhD or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Good

    Skills/Qualifications

    We are looking for a highly motivated candidate with a background in neuroscience and behavior and ideally in computational neurosciences. The candidate should demonstrate good skills in mouse handling and possibly in video tracking. Knowledge in machine/deep learning using Python will be appreciated. We also expect the candidate to be open-minded, curious and autonomous.

    Specific Requirements
  • Curriculum Vitæ
  • Cover letter
  • Grades and transcripts after High school, including rankings
  • Contact Information
  • Organisation/Company: CNRS
  • Department: UMR 7288 - Developmental Biology Institute of Marseille
  • Organisation Type: Public Research Institution
  • Website: https:// www. ibdm.univ-mrs.fr/ https: // www. inmed.fr/en/neurodevelopment-and-prader-willi-syndrome https: // www. lis-lab.fr/en/home/
  • E-Mail: laurent.fasano@univ-amu.fr francoise.muscatelli@inserm.fr severine.dubuisson@lis-lab.fr
  • Country: France
  • City: Marseille cedex09
  • Postal Code: 13288
  • Street: Parc Scientifique de Luminy, case 907
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