PhD studentship: Innate lymphoid cell crosstalk in the tumour and normal microenvironment
Department/location: Cancer Research UK Cambridge Institute
Deadline for application: Monday 14 November 2022
This is a unique opportunity for PhD study in the world-leading Cancer Research UK Cambridge Institute (CRUK CI), to start a research career in an environment committed to training outstanding cancer research scientists of the future. The Institute has excellent state-of-the-art facilities and research ranges from basic biology and computational biology through to translational cancer research and clinical application.
Postgraduate students play a pivotal role in the continuing success of our research programmes. If you are interested in contributing to our success, please find further information at: https: // www. cruk.cam.ac.uk/jobs-and- studentships/postgraduate-study
Dr Tim Halim wishes to appoint a student to work on the project entitled: Innate lymphoid cell crosstalk in the tumour and normal microenvironment.
For further information about the research group, including their most recent publications, please visit: https: // www. cruk.cam.ac.uk/research- groups/halim-group
Project details The immune system plays a critical role in many different aspects of cancer. Some immune cells are efficient at detecting and killing tumour cells, while in other instances inflammation is the underlying cause of cancer. Our lab is focused on a newly discovered group of immune cells, called innate lymphoid cells (ILC). Importantly, we have discovered that ILC have potent immune-regulatory properties that are likely to be critical in tumourigenesis. For instance, we recently discovered that different ILC sub- types counter regulate each other in the lung, with profound effects on metastatic seeding (Schuijs MJ, et al., Nature Immunology 2020).
This project aims to delineate the fundamental mechanism that regulate "good" versus "bad" inflammation in cancer or normal tissues. This understanding is critical for both treatment and prevention. This aim will be achieved through cutting-edge immunology techniques and reagents, which span from in vitro tumour-killing assays to monitoring the effect of ILC on tumour development in vivo. We use a combination of cutting-edge single cell technologies, including multi-parameter immunofluorescence imaging, flow cytometry and transcriptomic analysis. This work will pioneer a new area of cancer immunology research, and will ultimately provide important new drug targets in patients.
Preferred skills/knowledge The research project will involve the use of in vivo models, culture and genetic manipulation of primary immune cells, live cell imaging approaches, RNA-sequencing, quantitative proteomics, flow cytometry as well as basic cell biology and molecular biology. The ideal candidate requires a background in immunology, and would already have experience in one or more of the previously mentioned areas and would be highly motivated to drive an independent research project.
Funding This studentship is funded by Cancer Research UK and includes full funding for University and College fees and in addition, a stipend currently of £19,000 per annum, initially for 3 years, with funding for a further year possible as required.
Eligibility: No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second-class degree (or equivalent) in a relevant subject from any recognised university worldwide. Applicants with relevant research experience, gained through Master's study or while working in a laboratory, are strongly encouraged to apply.
The closing date for applications is 14 November 2022 with interviews expected to take place in the week beginning 16 January 2023.
How to apply: Please apply using the University Applicant Portal. For further information about the course and to access the applicant portal, go to: https: // www. postgraduate.study.cam.ac.uk/courses/directory/cvcrpdmsc Please select to commence study in Michaelmas term 2023 (October 2023).
To complete your online application, you need to provide the following:
Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.
Course Specific Question: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.
Supporting Document: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SW33402 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.Department/Location
Cancer Research UK Cambridge Institute, CambridgeReference
29 September 2022Closing date
14 November 2022