PhD Studentship in virology

University of Bern
January 05, 2023
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PhD Studentship in virology

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Institute of Virology and Immunology IVI, Mittelhäusern, Switzerland The IVI is Switzerland's reference laboratory for the diagnosis, monitoring and research of highly contagious animal diseases, including zoonoses. The IVI reports to the Swiss Federal Food Safety and Veterinary Office (FSVO) and contributes to teaching and research in the fields of virology and immunology, in cooperation with the Vetsuisse faculty of the University of Bern. The IVI provides a collaborative environment with experienced virologists, immunologists, veterinarians, and support teams within a unique high biosafety level containment laboratory.

Description

A PhD student position is available in the laboratory of Dr. Nicolas Ruggli to identify and study the function of non-essential genes of African swine fever virus (ASFV). The project relies on the general hypothesis that non- essential viral gene products exert accessory functions that are required primarily for the virus to combat the host's antiviral defense. Insights into these mechanisms at the molecular level will help understanding the complex immunopathogenesis of the disease and support vaccine development. To reach the research objectives, the successful candidate will use a broad range of cutting-edge techniques in virology, immunology, biochemistry and genomics to construct and characterize genetically-engineered ASFV in cell culture and in pigs, building on recent results from the laboratory 1, 2. The project is funded by Swiss National Science Foundation for 4 years. The successful applicant will be enrolled in the interfaculty PhD Program in Cellular and Biomedical Sciences of the University of Bern (www. gcb.unibe.ch).

1. Labroussaa F, Mehinagic K, Cippa V, Liniger M, Akarsu H, Ruggli N, Jores J. 2021. In-yeast reconstruction of the African swine fever virus genome isolated from clinical samples. STAR Protoc 2:100803. 2. Radulovic E, Mehinagic K, Wuthrich T, Hilty M, Posthaus H, Summerfield A, Ruggli N, Benarafa C. 2022. The baseline immunological and hygienic status of pigs impact disease severity of African swine fever. PLoS Pathog 18:e1010522.

Requirements

We are seeking a highly motivated candidate with a MSc degree in life sciences or veterinary medicine, with a solid background and interest in virology, immunology, genomics, and/or cellular biology. Interest in working with pigs is required but previous experience is not a prerequisite. The candidate should be proactive, have a highly collaborative spirit, and be able to work independently. Very good communication skills in English are essential. Basic knowledge of a Swiss national language would be helpful but not essential. Only outstanding applicants will be considered.

Entrance upon 01.03.2023 Application To apply, please send a single PDF file including: - a short cover letter stating your qualifications and specific interest for this position - a curriculum vitae including name and email of 2 references - copy of MSc diploma including transcripts if applicable Contact Dr. Nicolas Ruggli, https: // orcid.org/0000-0002-7679-6290 Email nicolas.ruggli@ivi.admin.ch Link to the institution https: // www. ivi.unibe.ch/research/virology/groupruggli/team/indexeng.html

www. unibe.ch

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