PhD studentship: Cellular plasticity in the senescence spectrum

University of Cambridge
November 14, 2022
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Offerd Salary:£21,000
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PhD studentship: Cellular plasticity in the senescence spectrum

PhD studentship : Cellular plasticity in the senescence spectrum

Department/location : Cancer Research UK Cambridge Institute

Deadline for application : 14 November 2022

This is a unique opportunity for PhD study in the world-leading Cancer Research UK Cambridge Institute (CRUK CI), to start a research career in an environment committed to training outstanding cancer research scientists of the future. The Institute has excellent state-of-the-art facilities and research ranges from basic biology and computational biology through to translational cancer research and clinical application.

Postgraduate students play a pivotal role in the continuing success of our research programmes. If you are interested in contributing to our success, please find further information at: https: // www. cruk.cam.ac.uk/jobs-and- studentships/postgraduate-study

Professor Masashi Narita wishes to appoint a student to work on the project entitled: Cellular plasticity in the senescence spectrum.

For further information about the research group, including their most recent publications, please visit: https: // www. cruk.cam.ac.uk/research-groups/narita- group

Project details

Senescence can be triggered by various stimuli in diverse cell contexts. We are particularly interested in oncogene-induced senescence (OIS), which occurs in the physiological diploid state as an early event during tumour initiation. OIS, which acts autonomously as a tumour suppressor mechanism, and tumour-initiating cells (TIC) are related but conceptually distinct. Our hypothesis is that senescence is not a singular entity but a continuum of dynamic and diverse cellular functionality and plasticity, constituting a senescence spectrum. We propose that mechanistic and functional insights into the OIS spectrum will reveal the relationship between OIS and TIC. We will address this question, using single-cell biology and epigenomic approaches in close collaboration with computational biologists.

Further reading

Chan & Narita. Gens Dev 2019: https:// genesdev.cshlp.org/content/33/3-4/127

Olan et al. Nat Commun 2020: https: // www. nature.com/articles/s41467-020-19878-4

Tomimatsu et al. Nat Aging 2021: https: // www. nature.com/articles/s43587-021-00147-y

Olan & Narita. Annu Rev Cell Dev Biol 2022: https: // www. annualreviews.org/doi/10.1146/annurev-cellbio-120420-013537

Preferred skills/knowledge

Experience in genomics methods and computational data analysis is beneficial but not essential.

Funding

This studentship is funded by Cancer Research UK and includes full funding for University and College fees and in addition, a stipend currently of £21,000 per annum, initially for 3 years, with funding for a further year possible as required.

Eligibility

No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second-class degree (or equivalent) in a relevant subject from any recognised university worldwide. Applicants with relevant research experience, gained through Master's study or while working in a laboratory, are strongly encouraged to apply.

How to apply

Please apply using the University Applicant Portal. For further information about the course and to access the applicant portal, go to: https: // www. postgraduate.study.cam.ac.uk/courses/directory/cvcrpdmsc Please select to commence study in Michaelmas term 2023 (October 2023).

To complete your online application, you need to provide the following:

Reference Request:

The names and contact details of two academic referees who have agreed to act on your behalf.

Course Specific Question:

Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.

Supporting Document:

Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results.

Deadline

The closing date for applications is 14 November 2022 with interviews expected to take place in the week beginning 16 January 2023.

Please quote reference SW33590 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Department/Location

Cancer Research UK Cambridge Institute, Cambridge

Reference

SW33590

Category

Studentships

Published

11 October 2022

Closing date

14 November 2022

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