22 May 2023Job Information
Institute of Organic Chemistry Polish Academy of Sciences
Chemistry » Organic chemistry
First Stage Researcher (R1)
4 Jun 2023 - 14:00 (Europe/Warsaw)
Type of Contract
Hours Per Week
Offer Starting Date
1 Oct 2023
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
Project title: Stereoselective dearomatization of nonactivated arenes via an „alkene walk” pathway: Rapid access to high-added value poly- and spirocyclic systems from readily available aromatic compounds.
Description of tasks:
The aim of this research proposal is to establish a new methodology for the stereoselective dearomatization of nonactivated arenes via the virtually unexplored retro-ene reaction of in situ generated benzylic diazenes (a so called “alkene walk” process), and subsequent transformation of the so formed active polyene species into chiral poly- and spirocyclic molecules. As a result, a new and versatile tool for the synthesis of high-value organic molecules from cheap and readily available benzylic alcohols, halides, aldehydes (in combination with organometallics) and monosilyl diazenes will be added to the organic chemist's toolbox. Moreover, the possibility of synthesis of advanced polyaromatic systems via an additional re-aromatization process will be tested.
Stereoselective dearomatizations, especially in non-activated arenes, allowing conversion of readily available planar aromatic compounds into three- dimensionally complex molecules with precise control of reaction site, regio- and stereoselectivity has long been an exciting challenge in organic synthesis. Due to their high resonance stabilization energy, dearomatizations of nonactivated arenes usually require the use of stoichiometric amounts of expensive and toxic transition metal activators or elevated temperatures and harsh reaction conditions. This makes achieving high stereoselectivity in these processes very difficult. In our approach aromatic substrates are initially transformed into highly active polyenes which can then further derivatized using the broad spectrum of well-established stereoselective reactions of alkenes and dienes conducted under mild reaction conditions, resulting in highly stereoselective dearomatizations. Further advantages of the method include high availability of substrates (in the case of chiral derivatives in both enantiomeric forms in high optical purity) and high chemo- and stereodiversity of the obtained products.
The candidate will be responsible for synthesizing of the starting materials and polyene intermediates, followed by an studies on their selective of transformations into variety of poly- and spirocyclic systems using selected literature protocols. The candidate will also be responsible for recording and interpreting spectral data, designing experiments, and preparing reports and materials for publications. Complementary theoretical studies on reaction mechanisms may be performed by the candidate or as part of a collaboration, depending on the scholar's interests.
The PhD candidate will also participate in the Institute scientific life by attending to group and institute seminars and lectures. The PhD candidate will also attend to advanced course devoted to modern organic chemistry and spectroscopy.Requirements
Chemistry » Organic chemistry
Master Degree or equivalent
IMPORTANT!!! A prerequisite for qualifying for the project is the PhD student status at the Warsaw PhD School in Natural and BioMedical Sciences (the interviews will be held from 26 June 2023 to 5 July 2023; the deadline for submitting documents to the doctoral school is June 4th, 2023), details are available on the Warsaw4PhD School website as well as the Institute of Organic Chemistry PAS website.
ATTENTION! In the title of the e-mail, please enter "Recruitment – Bartosz Zambroń"
Years of Research Experience
1 - 4
Benefits: private medical care package, co-financing of sports cards, and the possibility of accommodation at the Doctoral Hotel.
Work in young and dynamic research group;
List of required documents:
• Candidate's Curriculum Vitae
• description of scientific achievements including a list of publications, patents, monographs etc., a list of realized/ongoing research projects; a list of received research grants;
• diplomas and certificates confirming the course studies at the BSc and MSc level, with particular focus on the courses related to organic chemistry, completed courses, completed training, etc.;
• cover letter;
• letter of recommendation and references from previous supervisor;
• consent to the processing of the Candidate's personal data for the purposes of the competition;
Along with the required documents, please submit a signed consent to the processing of personal data available at: https: // www. icho.edu.pl/en/cooperations/career/
Candidate evaluation criteria:
Competition settlement date:2023-07-16
Project manager: dr hab. Bartosz Zambroń
Phone: +48 22 343 2141
e-mail: [email protected]
Institute of Organic Chemistry of the Polish Academy of Sciences
Kasprzaka 44/52 Street
Phone: +48 22 631 8788
e-mail: [email protected]
ATTENTION! In the title of the e-mail, please enter "Recruitment – Bartosz Zambron"
Website for additional job details
https: // www. icho.edu.pl/en/Work Location(s)
Number of offers available
Institute of Organic Chemistry PAS
Where to apply
https: // www. icho.edu.pl
+22 343 2141