Phd Student Position

21 May 2023

Job Information

Organisation/Company

University of Padova

Department

Department of Biology

Research Field

Biological sciences » Other

Researcher Profile

First Stage Researcher (R1)

Country

Italy

Application Deadline

5 Jun 2023 - 23:59 (Europe/Rome)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Oct 2023

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Recruitment is open for PhD students in the Genetics, Genomics and Bioinformatics curriculum of the Biosciences PhD program. My laboratory offers the opportunity to study epigenetic alterations occurring in the skeletal muscle of a mouse model that, after deletion of a DNA region comprising an enhancer, develops diabetes. Recently developed genomic techniques will be applied to evaluate in the chromatin structures and conformation.

Requirements

Research Field

Biological sciences » Other

Education Level

Master Degree or equivalent

Additional Information

Additional comments

A brief description of the project.

Skeletal muscle plays a key role in glucose homeostasis, being responsible for the uptake of the largest part of postprandial glucose from the blood. sAnk1.5 KO mice, which carry a deletion of 900 bp that eliminates part of a super enhancer region, show a reduced glucose tolerance. This project aims at performing an in-depth metabolic characterization of sAnk1.5 KO mice and identify epigenetic changes in skeletal muscles that result in altered glucose tolerance. Using chromosome conformation capture technologies (5-C, Hi-C) we expect to identify and characterize altered genomic DNA interactions caused by the deletion and correlate chromatin state with gene expression to better elucidate the involvement of skeletal muscle transcriptional profile in the development of T2D.

Website for additional job details

https: // www. biologia.unipd.it/news/leggi/news/call-for-application-for- further-…

Work Location(s)

Number of offers available

1

Company/Institute

Department of Biology - University of Padova

Country

Italy

State/Province

Padova

City

Padova

Postal Code

35121

Street

via U. Bassi 58/b

Geofield

Where to apply

E-mail

[email protected]

Contact

City

Padova

Website

https:// www. unipd.it

Street

via VIII Febbraio, 2

Postal Code

35122

STATUS: EXPIRED