PhD student in Neurochemistry (B)

Stockholm University
September 21, 2022
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atthe Department of Biochemistry and Biophysics. Closing date: 21 September 2022.

The Department is mainly located with the other Departments of Chemistry and Life Sciences in the Arrhenius Laboratories for Natural Sciences, which are situated in the northern part of the University Campus at Frescati. Some 300 people of which about 70 are PhD students work at the Department, engaged in internationally highly recognized research covering a broad range of subjects.

Project description Your studies in Neurochemistry will be in the project "Epigenomic regulation of human central nervous system development at the single-cell resolution".

The laboratory of Dr. Marek Bartosovic studies epigenetic programs underlying gene expression changes during development and in disease. We have previously developed new technologies to investigate the epigenome at the single-cell resolution and also pioneered high resolution spatially-resolved epigenomics on the DBiT platform. We also use cutting-edge molecular techniques such as scATAC-seq, CUT&Run, HiChIP, HiC, massive parallel reporter assay and genome/epigenome editing using CRISPR/Cas9 in order to understand the causal relationship between the epigenome and the transcriptome. We combine the wet lab approaches with deep bioinformatic analysis of the obtained data.

The intended project is aimed at mapping, perturbing and understanding the gene/epigenome regulatory networks underlying the development of the human central nervous system with focus on epistasis between multiple regulatory factors and their relevance for human genetically encoded traits. We will use combination of in vivo mapping (scCUT&Tag/scATAC-seq) and in vitro model systems (organoids and organotypic slice cultures) to gather insights into the interplay between multiple epigenetic modalities during lineage commitment in the human central nervous system. The project is intended to be part wet- lab and part computational and can be partially tailored to the student's interests. The computational expertise is present in the lab and training will be provided.

We are looking for a talented and motivated PhD student candidate with a strong background in wet-lab molecular techniques and strong interest in high- throughput techniques and neuroscience. Experience in one of the following fields is a plus - epigenetics, molecular neuroscience, organoids/organotypic slice cultures, CRISPR/Cas9 editing, bioinformatics, high-throughput profiling technologies (such as scRNA-seq/scATAC-seq, Hi-C, CRISPR screening, spatially-resolved techniques or similar) will be considered.

Qualification requirements In order to meet the general entry requirements, the applicant must have completed a second-cycle degree, completed courses equivalent to at least 240 higher education credits, of which 60 credits must be in the second cycle, or have otherwise acquired equivalent knowledge in Sweden or elsewhere.

In order to meet the specific entry requirements for acceptance in Neurochemistry with Molecular Neurobiology program the applicant must have passed courses within the first and second cycles of at least 120 credits in Chemistry/Life Sciences, including at least 15 credits Neurochemistry/Chemistry/Life Sciences at the second cycle level and a Degree Project (Thesis) also in Neurochemistry/Chemistry/Life Science of 30 credits.

Selection The selection among the eligible candidates will be based on their capacity to successfully complete the program. Important criteria when assessing this capacity are; documented knowledge and skill in the field of the thesis project, written and oral proficiency in English, the capacity for analytical thinking, the ability to collaborate, as well as creativity, initiative, and independence. The assessment will be based on previous experience and grades, the quality of the degree project, references, relevant experience, interviews and the candidate's written motivation for seeking the position.

Admission Regulations for Doctoral Studies at Stockholm University are available at: www. su.se/rules and regulations.

Terms of employment Only a person who will be or has already been admitted to a third-cycle programme may be appointed to a doctoral studentship.

The term of the initial contract may not exceed one year. The employment may be extended for a maximum of two years at a time. However, the total period of employment may not exceed the equivalent of four years of full-time study.

Doctoral students should primarily devote themselves to their own education, but may engage in teaching, research, and administration corresponding to a maximum of 20 % of a full-time position.

Please note that admission decisions cannot be appealed.

Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact For more information, please contact project leader Dr. Marek Bartosovic, marek.bartosovic@dbb.su.se.

General information about the PhD programs can be given by the Director of Doctoral Studies, Pia Ädelroth, pia.adelroth@dbb.su.se, or the Head of the Department, Martin Högbom, martin.hogbom@dbb.su.se.

Union representatives Ingrid Lander (Saco-S), telephone: +46 708 16 26 64, saco@saco.su.se, Alejandra Pizarro Carrasco (Fackförbundet ST/Lärarförbundet), telephone: +46 8 16 34 89, alejandra@st.su.se, seko@seko.su.se (SEKO), and PhD student representative, doktorandombud@sus.su.se.

Application Apply for the PhD student position at Stockholm University's recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the advertisement, and that it is submitted before the deadline.

Please include the following information with your application

  • Your contact details and personal data
  • Your highest degree
  • Your language skills
  • Contact details for 2–3 references
  • and, in addition, please include the following documents

  • Cover letter
  • CV – degrees and other completed courses, work experience and a list of degree projects/theses
  • Research proposal (no more than 3 pages) describing: – why you are interested in the field/project described in the advertisement – why and how you wish to complete the project – what makes you suitable for the project in question – outline a scientific question/project (maximum 1 page) you would be interested to work on. (The purpose of this document is not to design the successful candidate's doctoral studies, but to evaluate the scientific thinking of the applicant).

  • Degree certificates and grades confirming that you meet the general and specific entry requirements (no more than 6 files)

  • Letters of recommendation (no more than 6 files)
  • Degree projects/theses (no more than 6 files).
  • The instructions for applicants are available at: How to apply for a position.

    You are welcome to apply!

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