Phd Student In Biology (M/F)

Universities and Institutes of France
September 24, 2022
Offerd Salary:Negotiation
Working address:N/A
Contract Type:Temporary
Working Time:Full time
Working type:N/A
Job Ref.:N/A
  • Organisation/Company: CNRS
  • Research Field: Biological sciences
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 24/09/2022 23:59 - Europe/Brussels
  • Location: France › MONTPELLIER
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/12/2022
  • We previously reported that colon carcinogenesis, in both mice and human, is associated with a decreased number of PC on colonic fibroblasts (Rocha et al. EMBP J, 2014). The PhD project we offer will explore the biomedical potential of PC and associated pathways in CRC. For this, the student will use tissue specific knock out mice, relevant animal models for CRC, immunohistochemistry, organoid cell cultures, biochemistry and RNAseq. Moreover, we collaborate with the local University Hospital as well as different clinical centers in Europe for the analysis of patient biopsies. Our recent publications illustrate our experimental strategy (Guo et al. J. Clin Invest, 2021; Maurizy et al. bioRxiv 10.1101/2019.12.19.882712, now in press at Nat Commun).

    Colorectal cancer (CRC) is the third most common and deadly cancer worldwide. CRC is a molecularly highly heterogeneous disease and there is an urgent need to map the heterogeneity of CRC, to identify novel therapeutic intervention points as well as prognostic and predictive biomarkers. Crucial in the regulation of intestinal homeostasis and pathology is the crosstalk between epithelium lining the crypts and neighbouring fibroblasts. An underexplored trait in cellular crosstalk are primary cilia (PC), an antennae‐like structure extruding the surface of many mammalian cells. PC serve as sensors of environmental signals and regulate a range of signalling pathways associated with carcinogenesis.

    Web site for additional job details

    https: //

    Required Research Experiences
  • Biological sciences

  • None

    Offer Requirements
  • Biological sciences: Master Degree or equivalent

  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Institut de génétique moléculaire de Montpellier
  • Organisation Type: Public Research Institution
  • Website: https:// www.
  • Country: France
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