PhD Researchers (d/m/w) in Environmental Immunology

The Helmholtz-Centre for Environmental Research GmbH – UFZ
October 01, 2023
Offerd Salary:Negotiation
Working address:N/A
Contract Type:Other
Working Time:Negotigation
Working type:N/A
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The Helmholtz Centre for Environmental Research (UFZ) with its 1,100 employees has gained an excellent reputation as an international competence centre for environmental sciences. We are part of the largest scientific organisation in Germany, the Helmholtz association. Our mission: Our research seeks to find a balance between social development and the long-term protection of our natural resources.

The job

In the context of an interdisciplinary, international Horizon Europe project (coordination: Prof. Ana Zenclussen, UFZ), we will investigate the impact of endocrine-disrupting chemicals (EDCs) on human health. The project includes experiments with multiple innovative model systems such as primary cell cultures, 3D cultures, organoids and in vivo models as well as analysis of data obtained from various international cohort studies. The impact of relevant environmental chemicals on the immune system and how this impacts in health end points and pathologies will be investigated. Triangulation of in vitro, in vivo and cohort data will be the evidence base for policy briefs to inform the EU citizens about EDCs, their health effects and actions how their negative impact can be reduced.

Within the project we offer two PhD positions: 1) Focus on 3D culture models, placental organoids and alternative in vivo models such as zebrafish embryos 2) Focus on functional analysis of immune cell populations after chemical treatment and translation into mouse models

The positions will be filled subject to the formal approval of the funding body.

Your tasks
  • cell culture, cultivation of 3D organoids of placenta tissue
  • isolation and chemical treatment of immune cell populations
  • implementation of analytical techniques, e.g. flow cytometry, ELISA, mass cytometry
  • in vivo experiments with transgenerational, 3R-conform mouse models
  • in vivo experiments with zebrafish embryos
  • publication and presentation of scientific data
  • We offer
  • Excellent technical facilities which are without parallel
  • The freedom you need to bridge the difficult gap between basic research and close to being ready for application
  • Work in inter-disciplinary, multinational teams
  • Excellent links with national and international research networks
  • Excellent support and optimal subject-specific and general training with our HIGRADE graduate school
  • Your profile


  • successfully completed university degree (Diplom/M. Sc./comparable) in life sciences, biology or a comparable field
  • excellent skills in written and spoken English
  • extensive laboratory experience, especially with cell culture
  • ability to work in an international team, strong communication skills, high motivation
  • preferable:

  • permission to conduct animal experiments (Felasa certificate)
  • experience with publication and presentation of scientific results
  • From this employer

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