Location: The thesis will take place mainly at the CerCo and in the epilepsy department of the Toulouse University Hospital located in the immediate vicinity. The CerCo is a dynamic laboratory, with many students of all nationalities and profiles.
Intracranial electrical brain stimulations (EBS) are used to delineate the epileptogenic zone in pharmacoresistant epilepsy. However, current EBS protocols are empirical and limited. EBS parameters are not optimal. The direct impact of EBS on neuronal activity, on local field potentials and on widespread networks has seldom been explored. Very little is known about the modification of electrical parameters. This is not limited to epilepsy, but to all the fields where EBS are used (Parkinson's, psychiatric diseases). The DYNEUMICS project aims at exploring the multiscale effects of EBS (clinical, oscillations, neuronal dynamics) thanks to a EBS protocol including new EBS frequencies (tailored to each brain location and seizure onset pattern) and to new intracranial hybrid electrodes equipped with tetrodes, which are more efficient to isolate single neuron activity. Understanding changes in neuronal dynamics after EBS will help to specify optimal parameters and improve the exploration of pharmacoresistant epilepsy. The PhD student will work on this project which has started in 2021.
Skills required: Initial training in neuroscience with good experience in EEG signal processing. Coding in Matlab and Python. Basic math and physics. High level of rigour and organizational skills. Good social skills due to the different contexts of intervention and contact with patients in the hospital. Good level of written and spoken English.Additional comments
Please send a CV, cover letter, academic transcripts and Master's thesis.Web site for additional job details
https: // emploi.cnrs.fr/Offres/Doctorant/UMR5549-EMMBAR-001/Default.aspxRequired Research Experiences
Psychological sciences › Cognitive science
Psychological sciences › Psychology
Neurosciences: Master Degree or equivalent
Psychological sciences: Master Degree or equivalent
FRENCH: BasicContact Information