Umeå University is one of Sweden's largest institutions of higher education with over 35,000 students and 4,200 faculty and staff. We are characterised by world-leading research in several scientific fields and a multitude of educations ranked highly in international comparison. Umeå University is also the site of the pioneering discovery of the CRISPR-Cas9 genetic scissors - a revolution in genetic engineering that has been awarded the Nobel Prize in Chemistry.
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The Faculty of Medicine, which consists of 13 departments, is responsible for biomedical research and courses in the field of nursing and health care and has an extensive research and graduate education in more than 80 subjects.
The Department of Integrative Medical Biology is now announcing a Ph.D student position. The position is on fulltime for four years, starting 1st of December 2022 or upon agreement.
Description of the PhD-Project
Cannabinoid CB1 and dopamine D2 receptors can physically interact to form CB1/D2 heteromers that could constitute important therapeutic targets for a wide range of CNS disorders. However, the pharmacological importance of this interaction is yet to be determined on a molecular level. The main hypothesis we are addressing is that bidirectional allosteric interactions within CB1/D2 heteromers have functional consequences for the activity of receptor complexes in both the healthy and diseased brain. Hence, the main goal of this project is to use pharmacology to characterize the effects of different CB receptor ligands on CB1/D2 heteromer-specific signalling. The project will take advantage of the key strengths of different model systems - from transfected human cell lines, mouse/human stem cell-derived neuronal models, to a pharmacological model of schizophrenia in vivo using zebrafish.
The applicant is required to have completed a university level degree of at least 240 ECTS credits, of which at least 60 ECTS credits are at Master program level.
Specific admission requirements
In order to be admitted to postgraduate studies, it is required that the applicant has:
In addition, the applicant should, through university studies or other equivalent education, have gained basic theoretical knowledge in pharmacology or biomedicine and have experience of laboratory work and method development. Practical experience of cell culturing and experience of different biochemical methods of analysis is considered a very strong merit. The applicant should be able to work both independently and as part of a team, and high focus will be given to the candidate's potential collaborative skills.
Terms of employment
The appointment aims at a PhD degree and the main task of the PhD student is to pursue doctoral studies, which includes participation in research, seminars and courses. According to the Swedish Higher Education Ordinance (Chapter 12, Section 2), the decision on employment as a PhD student cannot be appealed. The employment is limited to four years full-time starting 2022-12-01 or upon agreement. The salary corresponds to the established salary level for doctoral employment.
The application shall be written in English or Swedish, documents must be in Word or pdf format. Applications must be submitted electronically using the e-recruitment system of Umeå University Varbi and be received no later than 2022-10-16 . A complete application should contain the following documents:
Other and contact
For more information please contact Professor Stig Jacobsson, firstname.lastname@example.org
You who are admitted to doctoral studies at the Faculty of Medicine will be enrolled in the faculty-wide doctoral education programme. The doctoral programme comprises 25 credits and is offered in two study variants: 25 credits spread over 8 terms (a total of 4 years) or over 12 terms (a total of 6 years), starting each autumn and spring semester. More information about the programme can be found on the faculty's web page for doctoral studies (https: // www. aurora.umu.se/en/organisation-and- management/organisation/faculties/faculty-of-medicine/doctoral-studies/).
Welcome to apply!
Umeå University strives to offer an equal environment where open dialogue between people with different backgrounds and perspectives lay the foundation for learning, creativity and development. We welcome people with different backgrounds and experiences to apply for the current employment.
We kindly decline offers of recruitment and advertising help.Type of employment Temporary position longer than 6 months
Contract type Full time First day of employment 2022-12-01 or upon agreement Salary monthly salary Number of positions 1 Working hours 100% City Umeå County Västerbottens län Country Sweden Reference number AN 2.2.1-1396-22 Contact
Published 16.Sep.2022 Last application date 16.Oct.2022 11:59 PM CEST
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