Cerebral small vessel disease (cSVD) is a disorder of the cerebral microvasculature causing ischemic and hemorrhagic strokes and vascular dementia. Chronic hypertension and type II diabetes lead to remodelling and thickening of arterioles resulting in hypoperfusion of the capillary networks. Hypoperfusion, impaired neurovascular coupling and increased blood brain barrier (BBB) permeability lead to brain tissue damage and reduced cognitive function. The current position concerns a project to look at the role of mechanotransduction by the endothelium in the development of cSVD. Funding for the position is awarded based on the candidate pursuing a double PhD between the Cardiovascular Research Institute CARIM at Maastricht University (NL) and the department of Cardiovascular Sciences at KU Leuven (BE). The doctoral work will mainly occur in Maastricht, however the candidate is expected to travel periodically to Leuven. This trans-disciplinary project will be co-supervised by Dr. Staals, a clinical neurologist at U Maastricht, Dr. Foulquier, a neuroscientist at U Maastricht, and Dr. Jones, an expert in mechanotransduction.
The project will involve significant histology and molecular biology techniques, as well as animal cognitive testing. The experimental protocols will be both in vitro and in vivo.
Tasks and responsibilities
You will be embedded in an interdisciplinary team where you will collaborate with other PhD-students and postdoctoral fellows from the participating research groups. Therefore, we are looking for a candidate who can quickly interact with different people and strives in a fast-paced environment.
,Conditions of employment
Fixed-term contract: 4 years (1+3).
What do we offer?
Your salary will be € 2,541 gross per month in the first year up to € 3,247 gross per month in the fourth year according to the PhD-candidate salary scale of the Collective Labor Agreement of the Dutch Universities (CAONU). On top of this, there is an 8% holiday and an 8.3% year-end allowance.
In addition to good primary employment conditions, UM also offers an attractive package of secondary employment conditions.
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www. maastrichtuniversity.nl > About UM > Working at UM.
,Employer Maastricht University
Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 22,000 students and about 5,000 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Science and Engineering, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience. For more information, visit www. maastrichtuniversity.nl.
For more information about this position, please contact: L. Jones, email [email protected] or S. Foulquier, email [email protected]
Deadline for submitting your application is March 15 2023. Start date is negotiable.
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