Phd Position (F/M) Transposable Elements And Life History Traits

Universities and Institutes of France
November 01, 2022
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Offerd Salary:Negotiation
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Contract Type:Temporary
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  • Organisation/Company: CNRS
  • Research Field: Physics
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 01/11/2022 23:59 - Europe/Brussels
  • Location: France › VILLEURBANNE
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/01/2023
  • The student will be part of Laboratoire de Biométrie et Biologie Évolutive (LBBE) (UMR CNRS 5558, Université Claude Bernard Lyon 1), within the "Genetics and Evolution of Interactions" (GEI) group. LBBE gathers scientists interested in various themes in evolution, ecology and health. The PhD student will be supervised by Marie Fablet (Associate Professor, IUF, LBBE) and Matthieu Boulesteix (Associate Professor, LBBE). The group has a long-term experience in TE dynamics and evolution, especially in Drosophila species. The group gathers know-hows in molecular biology, population genetics and bio-informatics specifically dedicated to TE biology. LBBE displays all necessary facilities for fly rearing and molecular biology experiments, in association with DTAMB (Development of Techniques and Molecular Analysis for Biodiversity, University Lyon 1 https:// www. dtamb.univ-lyon1.fr), and powerful computing resources, in association with PRABI (Pôle Rhone-Alpin de Bio- Informatique, https:// www. prabi.fr).

    All genomes contain parasite sequences called transposable elements (TEs), which are able to move and multiply along chromosomes. This phenomenon is called "transposition". Some recent research works found an increase in transposition rate related to ageing, however without knowing whether it is cause or consequence. Moreover, recent studies of the group showed that TEs could be activated upon viral infections in Drosophila. The aim of the project is to study the impacts of viral infections on transposition rates and induced consequences on the life span of individuals. In addition, transgenerational effects will be evaluated, through the study of TE-derived small interfering RNAs, in particular. Within this framework, the student will use a variety of viruses and drosophila strains (field strains and laboratory mutants) to perform sublethal viral infections, and analyze the consequences on life history traits and induced transposition rates, using molecular biology experiments and high throughput long-read sequencing data. The student will analyze the data using bioinformatic tools and a statistical approach. The PhD scholarship is funded by ANR LongevitY and Université Claude Bernard Lyon 1. We are looking for a meticulous, well-organized and creative person, with a background and interest in genomics and/or evolution of interactions, as well as skills in bio-informatics.

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/Doctorant/UMR5558-NATARB-042/Default.aspx

    Required Research Experiences
  • RESEARCH FIELD
  • Physics

  • YEARS OF RESEARCH EXPERIENCE
  • None

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Physics: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Laboratoire de Biométrie et Biologie Evolutive
  • Organisation Type: Public Research Institution
  • Website: https:// lbbe.univ-lyon1.fr/
  • Country: France
  • City: VILLEURBANNE
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