We are offering a PhD fellowship in Ichthyosis Research commencing on 15 May 2023 or as soon as possible hereafter.
Our group and research The Vogel group is a small ambitious research team of 7 people at the forefront of Serine protease research. We aim to uncover and understand the matriptase pathway and how it is regulated. The matriptase pathway is essential for epithelial development and homeostasis and involves several regulatory proteins.
Our research is focused on the serine proteases matriptase and prostasin (an activator of matriptase) and their inhibitors HAI-1 and HAI-2. We utilize mutations and SNPs found in the genes encoding these proteins to explore the role of the matriptase pathway under normal and diseased conditions. Mutations in the gene encoding matriptase have been found to cause a type of Ichthyosis (ARCI11), and mutations in the gene encoding HAI-2 cause Congenital Recessive Sodium Diarrhea, and dysregulation of matriptase causes cancer.
The group work as a team with a focus on giving each member the possibility to develop their full potential. Our overall goal is to translate our findings to the clinic.
Project description It is well documented that certain recessive mutations in the ST-14 gene encoding matriptase, cause a type of Ichthyosis (ARCI11). At present the only treatment for ichthyosis is moisturizers. The aim of this PhD project is to understand the molecular mechanisms behind ARCI11 and to develop a treatment possibly in the form of an enzyme replacement therapy.
The project involves a range of cell biology techniques including the use of human cell lines (polarized and non-polarized), recombinant expression in yeast, protein purification, mutagenesis, cell surface biotinylation, immunocytochemistry, western blotting, and more. Experience in one or more of these techniques will be an advantage.
The project requires you to develop novel assays, as this research area is still new and unlike any known proteolytic pathways. An interest in serine proteases with respect to enzyme kinetics, enzyme regulation, enzyme cascades, and/or enzyme specificity will be an advantage.
The principal supervisor is Associated Professor, Lotte K. Vogel , Department of Cellular and Molecular Medicine (ICMM); e-mail: [email protected] or mobile number: +45 3056 4396.
Start: 15 May 2023 or after agreement
Duration: 3 years as a PhD student
Job description Your key tasks as a PhD student at SUND are:
Key criteria for the assessment of applicants Applicants must have qualifications corresponding to a master's degree Biochemistry, Biology, Biomedicine or similar (equivalent of the Danish candidate, 3 + 2 years) related to the subject area of the project.
Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.
As a prerequisite for a PhD fellowship employment, your master's degree must be equivalent to a Danish master's degree. We encourage you to read more in the assessment database: https: // ufm.dk/en/education/recognition-and- transparency/find-assessments/assessment-database.
Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
Other important criteria are:
Place of employment The place of employment is at the Department of Cellular and Molecular Medicine, Panum, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a core facility for immunohistochemistry/immunocytochemistry.
Scientific environment The Department of Cellular and Molecular Medicine (ICMM) offers an ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with a high international impact focusing on the functional cell, its genetic components, and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high-quality research-based undergraduate and graduate teaching programs at the University of Copenhagen.
You can read more at https: // icmm.ku.dk/english/.
Terms of employment The average weekly working hours are 37 hours per week. The position is a fixed-term position limited to a period of 3 years.
It is conditioned upon the applicant's successful enrollment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. Enrollment at the Graduate School requires submission and acceptance of an application for the specific project formulated by the applicant (for more information, please see https: // healthsciences.ku.dk/phd/guidelines/).
The PhD study must be completed in accordance with The Ministerial Order on the PhD program (2013) and the faculty's rules on achieving the degree.
Salary, pension, and terms of employment are in accordance with the agreement between the Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary starts at DKK 28,896 / approx. EUR 3,878 (April 2023-level) plus pension.
Questions For specific information about the PhD fellowship, please contact the principal supervisor.
General information about PhD studies at the Faculty of Health and Medical Sciences is available at the Graduate School's website: https: // healthsciences.ku.dk/phd/guidelines/
Application procedure Your application must be submitted electronically by clicking ‘Apply now' below. The application must include the following documents in PDF format:
Application deadline: Monday 6 March 2023, 23.59 p.m. CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for formal assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills, and other requirements listed in the advertisement. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at https: // employment.ku.dk/faculty/recruitment-process/.
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The Faculty of Health and Medical Sciences comprises approximately 7,823 students, 1,886 PhD students and 5,100 employees. The faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.