PhD Candidate: Cell-state Heterogeneity and Drug-responses in Cancer

Employment

 0.8 - 1.0 FTE

Gross monthly salary

 € 2,770 - € 3,539

Required background

 Research University Degree

Organizational unit

 Faculty of Science

Application deadline

 24 September 2023

Are you a team-oriented PhD candidate with an interest in molecular developmental biology and single-cell genomics? Would you like to learn and work in a multidisciplinary team in an innovative laboratory environment? If so, come and Join the lively and world-class RIMLS-Science Institute and work towards understanding the mechanisms driving cellular behaviour.

We are looking for a PhD candidate to join our team to study the influence of cell-state heterogeneity to drug responses in cancer, with the aim to develop strategies to rationally control cell behaviour to achieve better therapeutic efficacy. This is a collaborative project between Radboud University in Nijmegen and the Vrije Universiteit (VU) and Netherlands Cancer Institute (NKI) in Amsterdam, and is funded by the Dutch Cancer Society. State-of-the- art single-cell multi-omics techniques (Radboud) and computational modelling (VU/NCI) will be used to map and understand cellular responses to drugs over time. Our team members generally perform both experimental and computational work as part of their training. As a member of the RIMLS-Science institute and Department of Molecular Developmental Biology, you will enter our four-year PhD programme at Radboud University. You will be able to develop your teaching skills by providing internship supervision, tutorials and (optionally) lectures as 10% of your position will be dedicated to teaching.

Profile

You should hold a Master's degree in Molecular or Cellular Biology, Biomedical Sciences, Molecular Life Sciences, or a related field.

You have experience in one or several of the following areas: cell culture, single-cell genomics techniques and next-generation sequencing.

You have experience in, or affinity with, computational analysis of (single-cell) genomics data.

You possess strong analytical skills and a problem-solving, result- oriented attitude.

You are a highly communicative and team science-minded professional. You have a good command of the English language (both verbal and written).

We are

This project will be carried out at the Department of Molecular Developmental Biology. Research in our team (headed by Dr Klaas Mulder) currently focuses on understanding what determines cellular responses/behaviour in developmental and disease contexts. Our team has a strong background in human stem and cancer cell biology, and in the development and application of innovative single-cell multi-omics technologies.

The Department of Molecular Developmental Biology is part of the Radboud Institute for Molecular Life Sciences (RIMLS-Science), which is one of the six research institutes of the Faculty of Science at Radboud University. The overarching aim of RIMLS-Science is to decipher molecular mechanisms of disease. Research areas of RIMLS-Science include epigenetics, stem-cell and developmental biology, and computational biology. The central research theme is regulation of gene expression during development and in health and disease. Important tools used at the institute include next-generation sequencing, mass spectrometry, single-cell multi-omics analysis, and computational analysis and method development. To perform state-of-the-art research, RIMLS-Science operates its own wet-lab and computational facilities. RIMLS-Science actively contributes to teaching activities in the Biology study programme at Radboud University. RIMLS-Science currently has about 50 researchers (including 30 PhD candidates and postdoctoral researchers) and provides a vibrant and international working environment.

Radboud University

We are keen to meet critical thinkers who want to look closer at what really matters. People who, from their expertise, wish to contribute to a healthy, free world with equal opportunities for all. This ambition unites more than 24,000 students and 5,600 employees at Radboud University and requires even more talent, collaboration and lifelong learning. You have a part to play!

We offer

It concerns an employment for 0.8 (5 year contract) - 1.0 (4 year contract) FTE.

The gross starting salary amounts to €2,770 per month based on a 38-hour working week, and will increase to €3,539 from the fourth year onwards (salary scale P).

You will receive 8% holiday allowance and 8.3% end-of-year bonus.

You will be employed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years (4 year contract) or 3.5 years (5 year contract).

You will be able to use our Dual Career and Family Care Services. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment and help your family settle in Nijmegen.

Working for us means getting extra days off. In case of full-time employment, you can choose between 30 or 41 days of annual leave instead of the legally allotted 20.

Additional employment conditions

Work and science require good employment practices. This is reflected in Radboud University's primary and secondary employment conditions. You can make arrangements for the best possible work-life balance with flexible working hours, various leave arrangements and working from home. You are also able to compose part of your employment conditions yourself, for example, exchange income for extra leave days and receive a reimbursement for your sports subscription. And of course, we offer a good pension plan. You are given plenty of room and responsibility to develop your talents and realise your ambitions. Therefore, we provide various training and development schemes.

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Would you like more information?

For questions about the position, please contact Klaas Mulder, Associate professor of Molecular Developmental Biology at [email protected].

Practical information and applying

You can apply until 24 September 2023, exclusively using the button below. Kindly address your application to Klaas Mulder. Please fill in the application form and attach the following documents:

A letter of motivation.

Your CV, including the contact details of 2-3 references.

The first round of interviews will take place on Wednesday 4 October. You would preferably begin employment as soon as possible. We can imagine you're curious about our application procedure. It offers a rough outline of what you can expect during the application process, how we handle your personal data and how we deal with internal and external candidates.

Apply now Application deadline 24 September 2023

We would like to recruit our new colleague ourselves. Acquisition in response to this vacancy will not be appreciated.

Dr Mulder, K.W. (Klaas)

Associate professor of Molecular Developmental Biology

[email protected]

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Last modified: 31 August 2023