Shifman lab at the Hebrew University of Jerusalem is looking for highly motivated and ambitious Ph. D. students to work on projects that involve engineering of therapeutic proteins and vaccines. The desired candidates have background in Computational Biology, Biochemistry, or Biophysics and are passionate about building new proteins from scratch. The lab has opportunities for either purely computational research or combination of computational and wet laboratory work.
Shifman group uses the tools of protein engineering, computational and structural biology and experimental biophysics to engineer novel proteins that bind with high affinity and high selectivity to any particular target protein. Such proteins could be used to decipher cellular signaling in health and disease and could be converted into imaging probes or drugs. The lab is interested in studying evolution of protein-protein interactions and in designing inhibitors and potential drugs for multiple targets and diseases starting from small protein domains. In addition, our group is involved in several international collaborations that include vaccine design, proteome- wide studies of binding specificity in enzymes, system biology studies of cancer networks, and large-scale protein engineering efforts at inhibiting cancer-related genes. Thus student exchanges are possible during the Ph. D. training. Our lab is a multidisciplinary group that include physicists, chemists, computer scientists, and biologists. More information about projects in the lab could be found here: https: // openscholar.huji.ac.il/shifmanlab/research-0Required Research Experiences
Chemistry › Biochemistry
1 - 4Offer Requirements
Biological sciences: Master Degree or equivalentSkills/Qualifications
High motivation for performing research and interest in protein engineering is the main requirement. Knowledge of biochemistry and protein structure and function is highly desirable. Experience with various biochemical and molecular biology techniques and/or programming skills are a plus.Specific Requirements
M. Sc. in Biochemistry, Biophysics, Computational Biology, or Biological Chemistry with a written M. Sc. thesis submitted. GPA 85 or higher during the B. Sc. studies. Two letters of recommendation from research supervisors.Contact Information