Marie Sklodowska-Curie Doctoral Researcher in Structural Mass Spectrometry in DNA Repair

University of Leeds
June 30, 2023
Offerd Salary:£48,640
Working address:N/A
Contract Type:Fixed Term (for 3 ye
Working Time:Full time
Working type:N/A
Ref info:N/A
Marie Sklodowska-Curie Doctoral Researcher in Structural Mass Spectrometry

in DNA Repair

Are you a rising star in the field of structural mass spectrometry (MS)? Would you like to contribute to the development of cutting-edge native MS, hydrogen-deuterium exchange (HDX) and other MS technology and apply it to analysis of nucleic-acid:protein interactions and the study of DNA repair complexes? Do you want to further your career and attain a PhD in one of the UK's leading research-intensive Universities?

You will join the recently funded European Doctoral Network (DN) RepState: DNA Repair State Machines (https: // www. RepState offers high- level doctoral training to 13 Doctoral Researchers (DRs) in six different countries. DRs will be supervised by researchers across the network, will be exposed to different sectors via planned placements, attend summer schools, and contribute to and organise workshops and conferences. You will be funded for 3 years and will pursue a doctoral degree during this time.

This DR position is based in the University of Leeds and concerns the investigation of key protein complexes involved in DNA repair using structural MS. In particular, the project involves application of methods such as native MS, ion mobility, HDX-MS, covalent labelling approaches and chemical crosslinking to study conformations of DNA repair state machines such as the UvrD:RNAP and UvrD:MutL complexes. In addition, it will allow the researcher to pioneer new MS approaches to DNA structural biology. This project will be supervised by Prof Sobott, in collaboration with several other researchers across the network.

Important eligibility rules for this position:

There are no restrictions on the nationality, but:

  • Applicants must, at the time of recruitment, have not yet been awarded a doctorate degree and be in the first 4 years (full-time equivalent) of their research careers. This is measured from the date that you obtained the degree which would entitle you to embark on a PhD.
  • At the time of recruitment, applicants must not have resided or carried out their main activity (work, studies, etc...) in the UK for more than 12 months in the 3 years immediately prior to their recruitment under the QSI project. Compulsory national service and/or short stays such as holidays are not taken into account.
  • Salary:

  • The Marie Skłodowska-Curie Doctoral Researcher living allowance is fixed at £48,640.00 per annum including the mobility allowance (£53,119.35 if eligible for the family allowance). This figure is before employer's and employee's deductions for national insurance and taxes per year, which will be paid in Sterling using an appropriate conversion rate .
  • To explore the post further or for any queries you may have, please contact:

    Frank Sobott, Chair in Biomolecular Mass Spectrometry

    Tel: +44 (0)113 343 2576 Email: [email protected]

    Location: Leeds - Main Campus

    Faculty/Service: Faculty of Biological Sciences School/Institute: School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology Category: Research Grade: Off grading structure Salary: £48,640 p.a. plus family allowance, dependent on eligibility in line with Marie Skłodowska-Curie Doctoral Network Working Time: 100% - We are open to discussing flexible working arrangements. Post Type: Full Time Contract Type: Fixed Term (for 3 years due to external funding) Release Date: Friday 02 June 2023 Closing Date: Friday 30 June 2023 Reference: FBSAS1061 Downloads: Candidate Brief

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