Funded Phd Opportunity - Msca Doctoral Network_Research In Connective Tissue Disorders

Universities and Institutes of Italy
December 23, 2022
Contact:N/A
Offerd Salary:Salary is complemented with a mobility allowance.
Location:N/A
Working address:N/A
Contract Type:Temporary
Working Time:Full time
Working type:N/A
Job Ref.:N/A
  • Organisation/Company: University of Padova
  • Research Field: Biological sciences
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 23/12/2022 00:00 - Europe/Brussels
  • Location: Italy › Padova
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 40
  • Offer Starting Date: 01/03/2023
  • Eu Research Framework Programme: HE / MSCA
  • Reference Number: 101072766
  • Marie Curie Grant Agreement Number: 4903050
  • 1 Doctoral (PhD) position

    Lab. Prof. Paolo Bonaldo

    https: // orcid.org/0000-0002-9571-8140

    Department of Molecular Medicina, University of Padova (Italy)

    Matrix Biology and Functional Genomics Lab

    Project: “Cellular Homeostasis ANd AGing in Connective TissuE Disorders (CHANGE)”

    CHANGE is a Marie-Skłodowska-Curie (MSCA) Doctoral Network focused on investigating connective tissue (CT) disorders to identify key players in age-related decline in physiological functions to develop therapeutic strategies and identify treatment targets for common diseases and frailty associated with aging.

    It is part of Horizon EUROPE programme of the European Union and 12 Doctoral Candidates (DC) will be appointed for 36 months each.

    CHANGE project - summary

    Lifespan has significantly increased but age-related disorders severely limit healthy aging and quality of life, and are a serious burden for the society. Musculoskeletal, cardio- and cerebrovascular failure are hallmarks of physical and cognitive decline in the elderly, but importantly, are also common traits in several early onset hereditary connective tissue disorders.

    In CHANGE, 12 young scientists will combine skills in musculoskeletal and vascular developmental and cellular biology and pathobiology related to aging, with expertise in cell culture, animal models, -omics, innovative high- resolution imaging and functional techniques. Exchange of knowledge and multidisciplinary collaboration between these fields of research and partners within the consortium will provide the skills, multidisciplinary knowledge and on-the-job training experience necessary to tackle the main aspects of biology of aging and age-related disorders affecting bone, cartilage, muscle and vasculature.

    PhD position at University of Padova:

    The project of the Doctoral Candidate (DC) will focus on genetic muscular diseases linked to collagen VI deficiency to investigate the transduction mechanisms of collagen VI in disease & premature ageing. The DC will use the available Col6a1−/− mouse model mimicking human muscular diseases to correlate the progression of phenotypes (apoptosis, autophagy, proliferation/stemness, and senescence hallmarks) during ageing in skeletal muscle and associated vascular system, and patient-derived cell cultures to evaluate the translational potential of the identified hallmark features.

    The candidate will be part of a Doctoral program of the University of Padova, within the CHANGE MSCA International Training Network funded by the European Union.

    The fellowship is for 36 months, starting from February-March 2023.

    MSCA salary standards, comprising fixed amounts of mobility and family allowances.

    Applications must be sent ASAP at: changeproject.msca@unipv.it

    Eligibility criteria
  • Applicants should not have resided or performed their main activity (work, studies, etc) in the country of the host institution for more than 12 months in the 3 year period immediately prior to the start date of the PhD research.

  • Applicants for the DC positions should be in their early research careers and not yet have been awarded a doctorate.

  • Selection process

    Short listed Applicants will be interview by the Trainee Committee.

    Additional comments Application

    To apply for this position, send your CV, motivation letter and at least a reference letter to the following email address: changeproject.msca@unipv.it

    Please state the DC reference (CHANGE DC number) in the subject line. If you would like to apply for more than one position, please indicate your first and second preference.

    Web site for additional job details

    https: // euraxess.ec.europa.eu/jobs/812870

    https: // marie-sklodowska-curie-actions.ec.europa.eu/

    Offer Requirements
  • REQUIRED EDUCATION LEVEL
  • Biological sciences: Master Degree or equivalent

  • REQUIRED LANGUAGES
  • ENGLISH: Excellent

    Skills/Qualifications
  • MSc, MRes, MEng, or equivalent in Life Science (Biology, Biochemistry, Biophysics, etc), Bioengineering, Physics or a related discipline.
  • Wet-lab experience in life science, Bioengineering, Physics or a related field
  • Interested and motivated to work in the field of age-related decline in physiological functions and of development of therapeutic strategies and identification of treatment targets for common diseases and frailty associated with aging.
  • Appreciation for interdisciplinary work and proactive drive to collaborate across disciplines
  • Applicants whose first language in not English may need to meet the English language requirements of the institute.
  • Specific Requirements

    MSCA-DN eligibility criteria

    There are strict eligibility requirements for the DC positions in a MSCA-DN. Please ensure that you qualify before applying, as ineligible candidates cannot be considered.

  • Applicants should not have resided or performed their main activity (work, studies, etc) in the country of the host institution for more than 12 months in the 3 year period immediately prior to the start date of the PhD research.
  • Applicants for the DC positions should be in their early research careers and not yet have been awarded a doctorate.
  • MSCA-DN offers an attractive salary and working conditions. A unique feature of MSCA-DN is that during the PhD research, DC PhD students will be given the opportunity to perform secondments at the facilities of other consortium members. DCs will benefit from a dedicated training program in the various fields of expertise organized and provided by the consortium partners. Salary is complemented with a mobility allowance.

    For more information on MSCA-DN, visit https:// ec.europa.eu/research/mariecurieactions/indexen.htm

    Contact Information
  • Organisation/Company: University of Padova
  • Department: Department of Molecular Medicine - DMM
  • Organisation Type: Higher Education Institute
  • Website: https: // www. medicinamolecolare.unipd.it/ricerca/laboratori/functional- genomic...
  • Country: Italy
  • City: Padova
  • State/Province: Italy
  • Postal Code: 35131
  • Street: Via Ugo Bassi, 58/B
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