Funded Phd Opportunity - Msca Doctoral Network_Research In Connective Tissue Disorders
Universities and Institutes of Italy
1 Doctoral (PhD) position
Lab. Prof. Paolo Bonaldo
https: // orcid.org/0000-0002-9571-8140
Department of Molecular Medicina, University of Padova (Italy)
Matrix Biology and Functional Genomics Lab
Project: “Cellular Homeostasis ANd AGing in Connective TissuE Disorders (CHANGE)”
CHANGE is a Marie-Skłodowska-Curie (MSCA) Doctoral Network focused on investigating connective tissue (CT) disorders to identify key players in age-related decline in physiological functions to develop therapeutic strategies and identify treatment targets for common diseases and frailty associated with aging.
It is part of Horizon EUROPE programme of the European Union and 12 Doctoral Candidates (DC) will be appointed for 36 months each.
CHANGE project - summary
Lifespan has significantly increased but age-related disorders severely limit healthy aging and quality of life, and are a serious burden for the society. Musculoskeletal, cardio- and cerebrovascular failure are hallmarks of physical and cognitive decline in the elderly, but importantly, are also common traits in several early onset hereditary connective tissue disorders.
In CHANGE, 12 young scientists will combine skills in musculoskeletal and vascular developmental and cellular biology and pathobiology related to aging, with expertise in cell culture, animal models, -omics, innovative high- resolution imaging and functional techniques. Exchange of knowledge and multidisciplinary collaboration between these fields of research and partners within the consortium will provide the skills, multidisciplinary knowledge and on-the-job training experience necessary to tackle the main aspects of biology of aging and age-related disorders affecting bone, cartilage, muscle and vasculature.
PhD position at University of Padova:
The project of the Doctoral Candidate (DC) will focus on genetic muscular diseases linked to collagen VI deficiency to investigate the transduction mechanisms of collagen VI in disease & premature ageing. The DC will use the available Col6a1−/− mouse model mimicking human muscular diseases to correlate the progression of phenotypes (apoptosis, autophagy, proliferation/stemness, and senescence hallmarks) during ageing in skeletal muscle and associated vascular system, and patient-derived cell cultures to evaluate the translational potential of the identified hallmark features.
The candidate will be part of a Doctoral program of the University of Padova, within the CHANGE MSCA International Training Network funded by the European Union.
The fellowship is for 36 months, starting from February-March 2023.
MSCA salary standards, comprising fixed amounts of mobility and family allowances.
Applications must be sent ASAP at: [email protected]
Eligibility criteriaApplicants should not have resided or performed their main activity (work, studies, etc) in the country of the host institution for more than 12 months in the 3 year period immediately prior to the start date of the PhD research.
Applicants for the DC positions should be in their early research careers and not yet have been awarded a doctorate.
Short listed Applicants will be interview by the Trainee Committee.
Additional comments ApplicationTo apply for this position, send your CV, motivation letter and at least a reference letter to the following email address: [email protected]
Please state the DC reference (CHANGE DC number) in the subject line. If you would like to apply for more than one position, please indicate your first and second preference.
Web site for additional job detailshttps: // euraxess.ec.europa.eu/jobs/812870
https: // marie-sklodowska-curie-actions.ec.europa.eu/
Offer RequirementsBiological sciences: Master Degree or equivalent
ENGLISH: Excellent
Skills/QualificationsMSCA-DN eligibility criteria
There are strict eligibility requirements for the DC positions in a MSCA-DN. Please ensure that you qualify before applying, as ineligible candidates cannot be considered.
MSCA-DN offers an attractive salary and working conditions. A unique feature of MSCA-DN is that during the PhD research, DC PhD students will be given the opportunity to perform secondments at the facilities of other consortium members. DCs will benefit from a dedicated training program in the various fields of expertise organized and provided by the consortium partners. Salary is complemented with a mobility allowance.
For more information on MSCA-DN, visit https:// ec.europa.eu/research/mariecurieactions/indexen.htm
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