Doctoral studies in the metabolic response to hypoxia in T cells

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The Johnson lab offers a stimulating, international research environment. We are part of the Department of Cell and Molecular Biology at the Karolinska Institute in Stockholm, Sweden, one of the world's leading medical universities. The lab is located in Biomedicum, a state-of-the-art research building on Solna campus. The labs primary focus is on the cellular and tissue response to low oxygen, or hypoxia.

Link to research group page: https: // ki.se/en/cmb/randall-johnsons-group

The project is concerned with the role of hypoxia induced metabolites and their roles in the modulation of T cell responses. The responses that the project will in particular focus on are those related to T cell immunotherapy.

The student will take on an independent project with a focus on a few specific metabolites that our group has found influence both molecular responses in T cells and in particular can alter their epigenetic states during activation following antigen recognition. A characterization of these responses and a better understanding of their mechanistic causes will be the chief focus of the doctoral work.

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well- educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

The student will need to be highly independent and self-directed. Additionally, the student will need to have good tissue culture training and skills, and extensive experience with molecular biology and immunology techniques, including western blotting, quantitative PCR, and FACs analysis.

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

- A personal letter and a curriculum vitae - Degree projects and previous publications, if any - Any other documentation showing the desirable skills and personal qualities described above - Documents certifying your general eligibility (see A above) - Documents certifying your specific eligibility (see B above)

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research - Analytical skill - Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

all