The University of Gothenburg tackles society's challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
The Department of Chemistry and Molecular Biology offers doctoral education within the fields of chemical sciences, molecular life sciences and environmental sciences. We conduct high quality international research using innovative techniques and modern equipment. It is our mission to provide you with the very best training, enabling you to reach your full potential and excel in your future endeavours.
From August 2023, we will be located in Natrium, a new building for natural and life sciences with access to modern education and research facilities.
Cellular molecules, such as DNA, RNA, and proteins, change across generations, creating heritable differences between cells and organisms and driving adaptation. Cancer, infection and resistance to chemotherapy and antibiotics are consequences of this molecular evolution. The Warringer research group combines evolutionary biology, population genetics and molecular and cellular biology to understand how changes to nuclear and organellar genomes influence aging, cancer and resistance to chemotherapy and antimicrobials. We work with model microbes, such as the baker's yeast Saccharomyces cerevisiae , and the bacterium Escherichia coli. We use both computational tools and molecular and cellular biology techniques to understand how genomes and traits change over generations.
The PhD education will be within the subject of molecular evolution, with a particular focus on the evolution of the mitochondria and the mitochondrial genome as a response to the production of reactive oxygen species during cellular respiration. The research will focus on understanding how and why deletions in the mitochondrial DNA of yeast cells emerge when the mitochondrial production of reactive oxygen species is high and how cells recover a normal content of intact mitochondrial DNA once this production declines. Mitochondrial production of reactive oxygen species and damage to mitochondrial molecules associate to the ageing of cells and organisms and to age-related diseases in humans.
General information about being a doctoral student at the University of Gothenburg can be found on the university's doctoral student pages.
https: // medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=true
DutiesThe PhD student will pursue a research education in molecular evolution and use yeast as a model organism. Both experimental and computer based bioinformatic research will be performed. The PhD student will experimentally evolve cell populations under high mitochondrial production of reactive oxygen radicals and follow the accumulation of mitochondrial and nuclear DNA changes, and the cells response to this, using DNA, RNA and proteinanalysis. The change in fitness of cell populations will be measured using a large-scale cell cultivation platform developed in the lab. The Phd student will make controlled changes to the DNA of cells using genetic engineering to test specific hypotheses regarding the regulatory and executive functions that are involved in the emergence of, and recovery from, mitochondrial deletions. For detailed information on the research subject, see https: // elifesciences.org/articles/76095. The PhD student is expected to take courses relevant to the research subject and to assist the teaching at undergraduate education programs in experimental biology and bioinformatics.
Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree.
As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.
EligibilityTo be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements: A person meets the general entry requirements for third-cycle courses and study programs if he or she:
To meet the specific entry requirements for third-cycle studies, applicants must: (i) have a second-cycle (advanced-level) degree in a relevant subject area in the natural sciences, or (ii) have completed studies for at least 60 higher education credits at a second-cycle level in relevant subject areas in the natural sciences, or (iii) have completed a corresponding program of relevance to the planned third-cycle program, in Sweden or in another country, or have equivalent qualifications.
Relevant for the planned third-cycle education
The specific entry requirements also include an acceptable command of spoken and written English. Guidelines for assessing English proficiency may include a minimum score of 550 on the TOEFL test (or 213 on the TOEFL-CBT, or 79 on the TOEFL-iBT).
Assessment criteriaIn selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
Type of employment: Fixed-term employment corresponding to four years full time studies
Extent: 50-100 %
Location: Department of Chemistry and Molecular Biology, Gothenburg
First day of employment : As soon as possible based on agreement
Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1993:100.
A new employment as a PhD student applies for a maximum of one year. The Appointment may be prolonged for up to two years at a time. The total employment period may not be longer than the equivalent of four years of full time doctoral studies.
University applies local agreement on salaries of graduate students.
Contact informationPrincipal investigator:
UnionsUnion representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
ApplicationIn order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.
You must include the following, in PDF format
If your degree is from a university outside of Sweden, check what you need to submit at https: // www. antagning.se/sv/Hur-du-anmaler-dig-och-haller- koll/magister-och-master/for-dig-med-utlandsk-kandidatexamen/dokument-fran- ditt-utbildningsland/ where you can also see what you need to submit in order to fulfill the English language requirement.
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
Applications must be received by: 2023-03-08
Information for International ApplicantsChoosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:
https: // www. gu.se/en/about-the-university/welcome-services https: // www. movetogothenburg.com/
The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.