Doctoral researcher (f/m/d) - Immunology Helmholtz-Zentrum für Infektionsforschung • Experimentelle Immunologie (EXIM) • Braunschweig

Germany Universities
January 25, 2023
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Open Positions 1

Time Span 01 Mar 2023 for 3 years Application Deadline 25 Jan 2023 Financing yes Type of Position

  • PhD - Individual Supervisor
  • PhD - Doctoral Programme
  • Field of Research

  • Mathematics / Natural Sciences
  • Medicine
  • Subjects Experimental Immunology Description The department Experimental Immunology, led by Prof. Dr. Jochen Hühn at the Helmholtz Centre for Infection Research (HZI), is offering the position as Doctoral Researcher (f/m/d) - Immunology

    The Helmholtz Centre for Infection Research GmbH (HZI) is a member of the Helmholtz Association of German Research Centers, the largest scientific organization in Germany. Scientists at the HZI develop strategies to better combat infectious diseases. Their goal is to develop novel approaches for the prevention, diagnosis and therapy of infectious diseases. To this end, they study bacterial and viral pathogens and their interaction with the immune system and explore new active ingredients.

    The department Experimental Immunology studies cellular players and molecular factors controlling the development and functional properties of various immune cells with a strong focus on the epigenetic fixation of immune cell fates (www. helmholtz-hzi.de/exim/). More recently, we became interested in how microbiota and infections influence these processes particularly during the neonatal period (Cording et al., 2014, Mucosal Immunol 7:359; Pezoldt et al., 2018, Nat Commun 9:3903; Zou et al., 2020, Eur J Microbiol Immunol 10:98; Wiechers et al., 2021, Cell Mol Immunol 18:1211; Beckstette et al., 2022, J Exp Med 219:e20210663; Pezoldt et al., 2022, Nat Commun 13:7227).

    Project description: The doctoral researcher will work on a project integrated into the Collaborative Research Centre (CRC)/Transregio (TRR) “Perinatal development of immune cell topology (PILOT)” funded by the German Research Foundation (DFG). PILOT encompasses 17 research projects, which all aim to explore mechanisms that direct perinatal differentiation of immune cells and their cellular environment. PILOT will dissect how preprogrammed developmental traits and perinatal exogenous cues integrate to steer immune cell differentiation, establish immune homeostasis and provide immunity to infections.

    The research project running at the HZI is entitled ‘Long-lasting consequences of early-life influenza A virus infection for the tissue-resident memory T cell niche and susceptibility to secondary infections'. In this project, the impact of neonatal respiratory infections on the postnatal lung development with a particular focus on the epigenome and functional properties of pulmonary cells contributing to the T cell niche in the lung will be studied using murine infection models. In addition to unraveling the cellular players and molecular mechanisms underlying the functional adaptations post neonatal infection, this project will also address the long-lasting consequences of early-life influenza A virus infection on the susceptibility to secondary infectious challenges during adulthood.

    Qualifications: We are looking for a highly motivated, creative and enthusiastic individual, able to do research independently as well as a part of an interdisciplinary and international team Master's Degree or equivalent in life sciences with a focus on immunology, molecular biology, genetics or cell biology Knowledge of and experience in immunology and molecular biology is required Experience on handling (neonatal) mice and basic knowledge in infection models and/or flow cytometry is considered an advantage Excellent English communication skills (written and spoken) Ability to work independently and as a part of an international team

    Disabled persons are given preference in the case of equal professional qualification. The HZI aims for professional equality between women and men. The position is suitable for part-time work.

    We offer: Challenging and varied tasks in a dynamic and international research environment Modern laboratories and state-of-the-art instrumentation Unique network of excellent partners to support your research endeavors Extensive further training opportunities Additional services of the public service A lively scientific community Flexible working hours and workplace design Buddy System for new doctoral researchers Family Office, Child Holiday Care A workplace at the Science Campus Brunswick-South 30 days vacation, (24.12. & 31.12. are considered as completely free days) An annual additional payment (Weihnachtsgeld) analogue to § 20 TVöD Social security included DO IT- PhD initiative https: // www. helmholtz-hzi.de/de/karriere/do-it-doktorandeninitiative Welcome Office

    The successful candidate will be integrated in the HZI International Graduate School for Infection Research (GS-FIRE) which provides an innovative structured PhD programme within the field of Infection Research https: // www. helmholtz-hzi.de/de/karriere/graduiertenschule/curriculum/.

    Starting date: March 1st, 2023 or later – initial contract for 3 years Salary: TVöD E13 (65%) Probation period: 6 months Published on: December 19, 2022 Closing date: January 25, 2023 Application: Applicants are required to complete the online application form here: https: // hzi.opencampus.net/ (Please select Job No. 214/2022).

    For more details regarding the position, please contact Prof. Dr. Jochen Hühn via email: jochen.huehn@helmholtz-hzi.de.

    Further information about the institute and the research group of Prof. Dr. Hühn can be found on our website: www. helmholtz-hzi.de/de/exim

    Working Language

  • English
  • Language of Dissertation

  • English
  • Required Documents

  • Others : https: // hzi.opencampus.net/
  • More Information https: // www. helmholtz- hzi.de/de/karriere/jobportal/doktorarbeiten/phd- theses/ansicht/job/details/doctoral-researcher-fmd-immunologie/

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