Department of Biology/Chemistry

University of Osnabrueck
March 01, 2023
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The Molecular Cell Biology Division in the Department of Biology/Chemistry at the University of Osnabrück is seeking to appoint

2 Research Assistants (m/f/d)

(salary grade E 13 TV-L, 65%)

to commence work at the earliest possible date. Each position is limited for three years.

Your Duties:

The successful candidates will participate in a DFG-funded research project aimed at elucidating cellular functions of sphingolipids, a class of multi- purpose biomolecules involved in life-death signalling, molecular sorting and membrane repair

  • PhD student #1 will combine functional assays with live cell imaging and correlative 3D electron microscopy to determine how membrane damage- induced sphingolipid scrambling and turnover promote survival of wounded cells;
  • PhD student #2 will exploit organellar lipidomics/proteomics, fluorescent biosensors and live cell microscopy to address how a disease- linked accumulation of sphingolipids in the ER affects the organelle's central role in stress signaling, membrane biogenesis and cargo export
  • Key references: Niekamp et al., 2022, Nature Communications 13, 1875; Sokoya et al., 2022, eLife 11, e79278; Pekkinen et al., 2019, JCI Insight 4, e126180; Holthuis & Menon, 2014, Nature 510, 48-57
  • You will have the opportunity to work towards a PhD outside working hours.

    Requirements:

  • Completed degree (M.Sc.) in biology, biochemistry or biophysics
  • Solid background in assay development with expertise in live cell microscopy, CRISPR/Cas9 technology and/or biomolecular mass spectrometry
  • Perseverance and aspiration to work in a strongly interdisciplinary research environment
  • Very good command of written and spoken English
  • We offer:

  • An exciting and cutting-edge research project
  • State-of-the-art instrumental infrastructure in a cooperative working environment (CellNanOS; https: // www. cellnanos.uni-osnabrueck.de/en)
  • Participation in the Collaborative Research Center SFB 1557 „Functional plasticity of cellular membrane networks” and its structured doctoral training and support programs (https: // irtg.uni- osnabrueck.de/application/sfb-1557.html)
  • Collegial cooperation in an interdisciplinary and international research team working on fundamental and disease-relevant aspects of lipid cell biology
  • Osnabrück University is a family-friendly university and is committed to helping working/studying parents balance their family and working lives.

    Osnabrück University seeks to guarantee equality of opportunity for women and men and strives to correct any gender imbalance in its schools and departments.

    If two candidates are equally qualified, preference will be given to the candidate with disability status.

    Applications including an informative letter of motivation, CV, publication list, certificates (BA/MA incl. Transcripts of Records) as well as the names and contact details of two academic referees should be sent as a single PDF- document until March 1st, 2023 to the Dean of the School of Biology/ Chemistry ([email protected]).

    Further information can be obtained from Prof. Dr. Joost Holthuis ([email protected]; Phone +49 541 969 7140) or by visiting our website: https: // holthuis-lab-uos.de/positions.

    We are very much looking forward to receiving your application.

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