2-Years Postdoctoral Position Available – Mechano-Chemical Control Of Jellyfish Regeneration (F/M)

Universities and Institutes of France
September 23, 2022
Offerd Salary:Negotiation
Working address:N/A
Contract Type:Temporary
Working Time:Full time
Working type:N/A
Job Ref.:N/A
  • Organisation/Company: CNRS
  • Research Field: Biological sciences › Biology
  • Researcher Profile: Recognised Researcher (R2)
  • Application Deadline: 23/09/2022 23:59 - Europe/Brussels
  • Location: France › BANYULS SUR MER
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Offer Starting Date: 01/12/2022
  • Quantification and manipulation of polarity and mechanical parameters in regenerating jellyfish, implementation of any necessary approach, interaction with the Modes team, writing of papers, supervision of students if desired.

    The project investigates how chemical and mechanical cues are integrated by a wounded jellyfish, in order to cope with random injuries in nature, and to switch on the appropriate repair program. We are asking a long-standing question of regenerative biology, uniquely accessible with our laboratory jellyfish, Clytia hemisphaerica: how is the choice between a healing-only and healing-and-regeneration program regulated? Building an integrative model for regeneration requires to consider both cellular and organismal levels, in an organism whose anatomical features and regenerative mode allow disentangling the different types of cues (mechanical and chemical signaling) and where technological developments enable in vivo measurements and functional approaches, at adult stages. The small and transparent jellyfish Clytia, where both mechanical and chemical cues were shown to participate in the recovery of forms (Sinigaglia et al., 2020, eLife), represents a unique and unexplored opportunity for addressing this knowledge gap. Exploiting the unique anatomy and the repair process of Clytia, this project will characterize the molecular and biophysical aspects of regeneration vs repair programs, and generate a stress-based simulation model. The model will explore the parameter space and direct further experimentation, allowing to start deciphering how different cues are integrated at the cellular and tissue level. This project will be performed in close collaboration with Dr. Carl Modes, a biophysicist expert in tissue mechanics, who leads the “Network Complexity and Systems Biophysics” group at the Max Planck Institute of Molecular Cell Biology and Genetics (Dresden, Germany).

    Our new group "Cnidarian Regeneration, Development and Evolution" is located in the Oceanographic Observatory of Banyuls-sur-Mer (Sorbonne University/CNRS), in the South of France. The project, under the direction of Dr. Chiara Sinigaglia, is funded by an ATIP-Avenir grant. More information can be found on the lab website at www. cnidevolab.com

    Eligibility criteria

    Background in biophysics preferred but not essential, experience with some of the following approaches requested: microscopy, live imaging, transgenesis, molecular biology and functional approaches, non-conventional laboratory organisms.

    Web site for additional job details

    https: // emploi.cnrs.fr/Offres/CDD/UMR7232-DIDPEU-019/Default.aspx

    Required Research Experiences
  • Biological sciences

  • 1 - 4

  • Biological sciences › Biology

  • 1 - 4

    Offer Requirements
  • Biological sciences: PhD or equivalent

  • FRENCH: Basic

    Contact Information
  • Organisation/Company: CNRS
  • Department: Biologie intégrative des organismes marins
  • Organisation Type: Public Research Institution
  • Website: https:// biom.obs-banyuls.fr/
  • Country: France
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